ArticleMolecular biology international2011
Glycolysis in the african trypanosome: targeting enzymes and their subcellular compartments for therapeutic development.
Article in Molecular biology international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Intrinsic protein disorder reveals divergent signaling architectures and lifestyle adaptation inbioRxiv : the preprint server for biology · 2026Article
- To Explore Potential Natural Inhibitors of Cysteine Proteases to Combat Human African Trypanosomiasis and Chagas Disease.Current medicinal chemistry · 2026Review
- Malate dehydrogenase in parasitic protozoans: roles in metabolism and potential therapeutic applications.Essays in biochemistry · 2024Review
- Measuring Dynamic Glycosomal pH Changes in Living Trypanosoma brucei.Journal of visualized experiments : JoVE · 2024Article
- Polyamine Metabolism for Drug Intervention in Trypanosomatids.Pathogens (Basel, Switzerland) · 2024Review
- Article
- Trypanosoma brucei brucei Induced Hypoglycaemia Depletes Hepatic Glycogen and Altered Hepatic Hexokinase and Glucokinase Activities in Infected Mice.Acta parasitologica · 2022Article
- Proposed Mechanism for the Antitrypanosomal Activity of Quercetin and Myricetin Isolated fromMolecules (Basel, Switzerland) · 2021Article
- Repurposing bioenergetic modulators against protozoan parasites responsible for tropical diseases.International journal for parasitology. Drugs and drug resistance · 2020Article
- Reduced fasting blood glucose levels following relapse in diminazene aceturate (DinazeneJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2019Article
- The crystal structure of glucokinase from Leishmania braziliensis.Molecular and biochemical parasitology · 2019Article
- FRET Flow Cytometry-Based High Throughput Screening Assay To Identify Disrupters of Glucose Levels in Trypanosoma brucei.ACS infectious diseases · 2018Article
- pH regulation in glycosomes of procyclic formThe Journal of biological chemistry · 2017Article
- Molecular and biochemical characterization of Eimeria tenella hexokinase.Parasitology research · 2016Article
- Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase.Molecular and biochemical parasitology · 2015Article
- Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes.PLoS neglected tropical diseases · 2015Article
- Peptide-targeted delivery of a pH sensor for quantitative measurements of intraglycosomal pH in live Trypanosoma brucei.Biochemistry · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Subspecies of the African trypanosome, Trypanosoma brucei, which cause human African trypanosomiasis, are transmitted by the tsetse fly, with transmission-essential lifecycle stages occurring in both the insect vector and human host. During infection of the human host, the parasite is limited to using glycolysis of host sugar for ATP production. This dependence on glucose breakdown presents a series of targets for potential therapeutic development, many of which have been explored and validated as therapeutic targets experimentally. These include enzymes directly involved in glucose metabolism (e.g., the trypanosome hexokinases), as well as cellular components required for development and maintenance of the essential subcellular compartments that house the major part of the pathway, the glycosomes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.