ArticleRadiology research and practice2011
Differential effects of alpha-particle radiation and x-irradiation on genes associated with apoptosis.
Article in Radiology research and practice, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Experimental Setups for In Vitro Studies on Radon Exposure in Mammalian Cells-A Critical Overview.International journal of environmental research and public health · 2023Review
- Article
- Identification of gene-based responses in human blood cells exposed to alpha particle radiation.BMC medical genomics · 2014Article
- Article
- Gene expression profiling upon (212) Pb-TCMC-trastuzumab treatment in the LS-174T i.p. xenograft model.Cancer medicine · 2013Article
- Effects of α-Particle Radiation on MicroRNA Responses in Human Cell-Lines.The open biochemistry journal · 2012Article
- Genomic profiling of a human leukemic monocytic cell-line (THP-1) exposed to alpha particle radiation.TheScientificWorldJournal · 2012Article
- Transcriptional and secretomic profiling of epidermal cells exposed to alpha particle radiation.The open biochemistry journal · 2012Article
- A comparitive assessement of cytokine expression in human-derived cell lines exposed to alpha particles and X-rays.TheScientificWorldJournal · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined differential effects of alpha-(α-) particle radiation and X-rays on apoptosis and associated changes in gene expression. Human monocytic cells were exposed to α-particle radiation and X-rays from 0 to 1.5 Gy. Four days postexposure, cell death was measured by flow cytometry and 84 genes related to apoptosis were analyzed using real-time PCR. On average, 33% of the cells were apoptotic at 1.5 Gy of α-particle radiation. Transcript profiling showed statistical expression of 15 genes at all three doses tested. Cells exposed to X-rays were <5% apoptotic at ~1.5 Gy and induced less than a 2-fold expression in 6 apoptotic genes at the higher doses of radiation. Among these 6 genes, Fas and TNF-α were common to the α-irradiated cells. This data suggests that α-particle radiation initiates cell death by TNF-α and Fas activation and through intermediate signalling mediators that are distinct from X-irradiated cells.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.