ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2011
Genetic variation in the association of air pollutants with a biomarker of vascular injury in children and adolescents in Isfahan, Iran.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Human Genetic Variation in F3 and Its Impact on Tissue Factor-Dependent Disease.Seminars in thrombosis and hemostasis · 2024Review
- Developing and Testing the Reliability and Validity of the Brief Haze Weather Health Protection Behavior Assessment Scale-Adolescent Version (BHWHPBAS-AV).Frontiers in pediatrics · 2020Article
- Adolescent Haze-Related Knowledge Level Study: A Cross-Sectional Survey With Sensitivity Analysis.Frontiers in public health · 2020Article
- Association of benzene exposure with insulin resistance, SOD, and MDA as markers of oxidative stress in children and adolescents.Environmental science and pollution research international · 2018Article
- Development and testing of the reliability and validity of the adolescent haze related knowledge awareness assessment scale (AHRKAAS).BMC public health · 2018Article
- Exposure to ambient air particulate matter and non-alcoholic fatty liver disease.World journal of gastroenterology · 2013Review
- Environmental air pollution and acute cerebrovascular complications: an ecologic study in tehran, iran.International journal of preventive medicine · 2012Article
- Synergistic effects of genetic polymorphism and air pollution on markers of endothelial dysfunction in children.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012Article
- Association of particulate air pollution and secondhand smoke on endothelium-dependent brachial artery dilation in healthy children.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012Article
- Obesity and air pollution: global risk factors for pediatric non-alcoholic fatty liver disease.Hepatitis monthly · 2011Article
- Overweight, air and noise pollution: Universal risk factors for pediatric pre-hypertension.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2011Article
- What health professionals should know about the health effects of air pollution and climate change on children and pregnant mothers.Iranian journal of nursing and midwifery research · 2011Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome experimental studies revealed that exposure to air pollution increases the expression of tissue factor (TF) in atherosclerotic lesions. We aimed to investigate the role of TF +5466A>G (rs3917643) polymorphism in the association of air pollution on serum levels of TF as a biomarker of vascular injury in children.
methodsThis cross-sectional study was conducted among 110 children, consisting of 58 (52.8%) girls and 52 (47.2%) boys with a mean age of 12.7 ± 2.3 years, living in Isfahan, Iran. Enzyme-linked immunosorbent assay were used for measurement of serum TF. Genotype of +5466A>G (rs3917643) polymorphism was determined by the polymerase chain reaction-restriction length fragment polymorphism (PCR-RFLP) method.
resultsWe identified 2 individuals with +5466AG genotype and 108 homozygous for the +5466A allele (no +5466GG homozygotes). The mean pollution standards index (PSI) value was at moderate level, the mean particular matter measuring up to 10 μm (PM(10)) was more than twice the normal level. Multiple linear regression analysis showed that after adjustment for confounding factors (weight status, dietary and physical activity pattern), serum TF level had significant relationship with PSI (beta: 0.55, SE: 0.07, p<0.000) and PM(10) (beta: 0.51, SE: 0.03, p=0.001).
conclusionsIn spite of similar genetic polymorphism of TF, air pollutants might have an independent association with systemic inflammatory and coagulation responses. The harmful effects of air pollutants on the first stages of atherosclerosis in the pediatric age group should be underscored in primordial and primary prevention of chronic diseases.
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22091301PMC3214390W269087912What OpenQuestion holds
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