Evidence map›Paper›PMID 22090784›Full record

ReviewWorld journal of gastroenterology2011

Heme oxygenase-1 system and gastrointestinal inflammation: a short review.

Xiao Zhu, Wen-Guo Fan, Dong-Pei Li, Hsiangfu Kung, Marie Cm Lin

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
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  18. Sesamol suppresses the inflammatory response by inhibiting NF-κB/MAPK activation and upregulating AMP kinase signaling in RAW 264.7 macrophages.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015
    Article
  19. Cytoprotective role of heme oxygenase-1 in liver ischemia reperfusion injury.International journal of clinical and experimental medicine · 2015
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xiao ZhuCancer Institute, Affiliated Tumor Hospital, Guangzhou Medical University, Guangzhou 510095, Guangdong Province, China. bioxzhu@yahoo.com
Wen-Guo Fan
Dong-Pei Li
Hsiangfu Kung
Marie Cm Lin
Guangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heme oxygenase-1 (HO-1) system catalyzes heme to biologically active products: carbon monoxide, biliverdin/bilirubin and free iron. It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes. A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date. The ability to upregulate HO-1 by pharmacological means or using gene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future.

Indexed as

AnimalsBilirubinBiliverdineGastrointestinal TractHeme Oxygenase-1HumansInflammationIronIsoenzymesNitric Oxide Synthase Type IIPolymorphism, GeneticPromoter Regions, GeneticUp-RegulationBilirubinBiliverdineHeme Oxygenase-1IronIsoenzymesNitric Oxide Synthase Type IIGastrointestinal inflammationHeme oxygenase-1

Identifiers

PMID22090784
PMCPMC3214703
OpenAlexW2121133963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.