ArticleJournal of cytology2011
Efficacy of oral brush cytology in the evaluation of the oral premalignant and malignant lesions.
Article in Journal of cytology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Diagnostic Accuracy of Screening of Lip and Oral Cavity Cancers or Potentially Malignant Disorders (PMD) by Frontline Workers: A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2022Pooled it
- Article
- A critique to the article "Pina PSS, Mendes AT, Correa L, Coracin FL, de Sousa SCOM. The role of exfoliative cytology in diagnosis of oral lesions. Clin Oral Investig. 2024 Dec 6;29(1):2. doi: 10.1007/s00784-024-06080-9. PMID: 39641812."Clinical oral investigations · 2025Article
- Exploring the potential of interdental brush in oral cytology: a pilot study on sampling efficiency.BMC oral health · 2025Observational
- Exfoliated Oral Mucosal Cell Micronucleus Frequency Evaluation in Healthy Individuals, Tobacco Users, and Patients with Potentially Malignant Disorders: An Analytical Comparative Study.Journal of pharmacy & bioallied sciences · 2024Article
- Adjunctive aids for the detection of oral squamous cell carcinoma and oral potentially malignant disorders: A systematic review of systematic reviews.The Japanese dental science review · 2024Review
- Reconstructing oral cavity tumor evolution through brush biopsy.Scientific reports · 2024Article
- Effect of different types of smoking on oral health and on cellular changes in oral mucosa.The Saudi dental journal · 2024Article
- New Horizons and Prospects in Oral Cancer Detection.Journal of pharmacy & bioallied sciences · 2024Review
- Screening of Oral Squamous Cell Carcinoma Through Color Intensity-Based Textural Features.Cureus · 2024Article
- Micronuclei detection in oral cytologic smear: does it add diagnostic value?Journal of the Egyptian National Cancer Institute · 2023Article
- Cytomorphometric Analysis of Oral Buccal Mucosa of Dental Colleges' Students in Sulaimani City.Diagnostics (Basel, Switzerland) · 2023Article
- Smart Diagnostics: Combining Artificial Intelligence and In Vitro Diagnostics.Sensors (Basel, Switzerland) · 2022Article
- Evaluation of Role of Visual Inspection Using Acetic Acid (VIA) and Exfoliative Cytology in Screening and Early Detection of Oral Premalignant Lesions and Oral Cancer.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Nuclear F-actin Cytology in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma.Journal of dental research · 2021Article
- Article
- Case Report: Hidden Oral Squamous Cell Carcinoma in Oral Somatic Symptom Disorder.Frontiers in psychiatry · 2021Article
- Oral cancer diagnosis and perspectives in India.Sensors international · 2020Review
- Development of a cytology-based multivariate analytical risk index for oral cancer.Oral oncology · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn the present study, oral brush cytology of premalignant and malignant lesions was performed using tooth brush. The cytopathological diagnosis of brush cytology was compared with that of punch biopsy. The reliability of oral brush cytology using tooth brush was assessed in terms of sensitivity and specificity. MATERIALS AND
methodsA total of 67 patients, 32 premalignant lesions and other 35 frank oral carcinomas, were included in the study. All patients underwent oral brush cytology using a toothbrush followed by punch biopsy. Sensitivity, specificity, positive and negative predictive values were calculated. Cytopathology and histopathology of premalignant and malignant lesions were compared using Mann-Whitney U test. Inter- and intra-examiner reliability was calculated using Rank-correlation coefficient.
resultsTwo in premalignant group and five in malignant group were marked insufficient. 18% of cases were false negatives. The sensitivity, specificity, positive predictive value and negative predictive value were 77%, 100%, 100% and 38%, respectively. Statistical analysis showed P>0.05, suggesting that there is no significant difference between histopathology and brush cytology in assessing both premalignant and malignant lesions. Inter- and intra-examiner reliability were 99.22% and 99.77%, respectively.
conclusionBrush cytology using a tooth brush is reliable and can be easily performed with less cost and discomfort to the patient. It is useful in those situations when a patient refuses to have a biopsy performed or when medically compromised patients would be exposed to unnecessary surgical risks. It can be used for screening for suspicious oral lesions, and may have applications in resource-challenged areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.