ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Multimodal quantitative magnetic resonance imaging of thalamic development and aging across the human lifespan: implications to neurodegeneration in multiple sclerosis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
- Mediating effect of cognitive reserve on associations between processing speed and memory in older adults with and without multiple sclerosis.Neuropsychology · 2026Article
- Brain Atrophy and Cognitive Impairment in Primary and Secondary Progressive Multiple Sclerosis Cohort-Similar Progressive MS Phenotype.International journal of molecular sciences · 2025Article
- Lifespan neurodegeneration of the human brain in multiple sclerosis.Human brain mapping · 2023Article
- Lifespan Neurodegeneration Of The Human Brain In Multiple Sclerosis.bioRxiv : the preprint server for biology · 2023Article
- The Significance of Hypothalamic Inflammation and Gliosis for the Pathogenesis of Obesity in Humans.Endocrine reviews · 2023Review
- Thalamic nuclei atrophy at high and heterogenous rates during cognitively unimpaired human aging.NeuroImage · 2022Article
- Cognitive Decline in Older People with Multiple Sclerosis-A Narrative Review of the Literature.Geriatrics (Basel, Switzerland) · 2022Review
- Longitudinal neuroimaging evaluation of the corticospinal tract in patients with stroke treated with autologous bone marrow cells.Stem cells translational medicine · 2021Article
- Pilot multi-site and reproducibility study of hypothalamic gliosis in children.Pediatric obesity · 2021Article
- Frontal aslant tracts as correlates of lexical retrieval in MS.Neurological research · 2020Article
- Initial evidence for hypothalamic gliosis in children with obesity by quantitative T2 MRI and implications for blood oxygen-level dependent response to glucose ingestion.Pediatric obesity · 2019Article
- Yakovlev's Basolateral Limbic Circuit in Multiple Sclerosis Related Cognitive Impairment.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2018Article
- Thalamic functional connectivity and its association with behavioral performance in older age.Brain and behavior · 2018Article
- Effects of Rhythmic Auditory Cueing in Gait Rehabilitation for Multiple Sclerosis: A Mini Systematic Review and Meta-Analysis.Frontiers in neurology · 2018Article
- Quantitative Limbic System Mapping of Main Cognitive Domains in Multiple Sclerosis.Frontiers in neurology · 2018Article
- Altered Microstructural Caudate Integrity in Posttraumatic Stress Disorder but Not Traumatic Brain Injury.PloS one · 2017Article
- Disorganized attachment in infancy predicts greater amygdala volume in adulthood.Behavioural brain research · 2016Article
- Entorhinal Cortex Thickness across the Human Lifespan.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2016Article
- Article
- Simultaneous TTomography (Ann Arbor, Mich.) · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The human brain thalami play essential roles in integrating cognitive, sensory, and motor functions. In multiple sclerosis (MS), quantitative magnetic resonance imaging (qMRI) measurements of the thalami provide important biomarkers of disease progression, but late development and aging confound the interpretation of data collected from patients over a wide age range. Thalamic tissue volume loss due to natural aging and its interplay with lesion-driven pathology has not been investigated previously. In this work, we used standardized thalamic volumetry combined with diffusion tensor imaging, T2 relaxometry, and lesion mapping on large cohorts of controls (N = 255, age range = 6.2-69.1 years) and MS patients (N = 109, age range = 20.8-68.5 years) to demonstrate early age- and lesion-independent thalamic neurodegeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.