ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Use dependence of presynaptic tenacity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Linking spontaneous and stimulated spine dynamics.Communications biology · 2023Article
- Activity Dependent and Independent Determinants of Synaptic Size Diversity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Cooperative stochastic binding and unbinding explain synaptic size dynamics and statistics.PLoS computational biology · 2017Article
- Opposing Effects of Maternal Hypo- and Hyperthyroidism on the Stability of Thalamocortical Synapses in the Visual Cortex of Adult Offspring.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Relative Contributions of Specific Activity Histories and Spontaneous Processes to Size Remodeling of Glutamatergic Synapses.PLoS biology · 2016Article
- Remodeling and Tenacity of Inhibitory Synapses: Relationships with Network Activity and Neighboring Excitatory Synapses.PLoS computational biology · 2015Article
- Presynaptic active zones in invertebrates and vertebrates.EMBO reports · 2015Review
- Synaptic size dynamics as an effectively stochastic process.PLoS computational biology · 2014Article
- Hybrid multiphoton volumetric functional imaging of large-scale bioengineered neuronal networks.Nature communications · 2014Article
- Dynamic mechanisms of neuroligin-dependent presynaptic terminal assembly in living cortical neurons.Neural development · 2014Article
- Synaptic vesicle recycling: steps and principles.The EMBO journal · 2014Review
- Activity-dependent adaptations in inhibitory axons.Frontiers in cellular neuroscience · 2013Review
- Matching dynamics of presynaptic and postsynaptic scaffolds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Increased axonal bouton dynamics in the aging mouse cortex.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Release properties of individual presynaptic boutons expressed during homosynaptic depression and heterosynaptic facilitation of the Aplysia sensorimotor synapse.Frontiers in cellular neuroscience · 2013Article
- Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Formation of Golgi-derived active zone precursor vesicles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Synaptic vesicle pools and dynamics.Cold Spring Harbor perspectives in biology · 2012Review
- Recruitment of resting vesicles into recycling pools supports NMDA receptor-dependent synaptic potentiation in cultured hippocampal neurons.The Journal of physiology · 2012Article
- Long-term relationships between cholinergic tone, synchronous bursting and synaptic remodeling.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Recent studies indicate that synaptic vesicles (SVs) are continuously interchanged among nearby synapses at very significant rates. These dynamics and the lack of obvious barriers confining synaptic vesicles to specific synapses would seem to challenge the ability of synapses to maintain a constant amount of synaptic vesicles over prolonged time scales. Moreover, the extensive mobilization of synaptic vesicles associated with presynaptic activity might be expected to intensify this challenge. Here we examined the ability of individual presynaptic boutons of rat hippocampal neurons to maintain their synaptic vesicle content, and the degree to which this ability is affected by continuous activity. We found that the synaptic vesicle content of individual boutons belonging to the same axons gradually changed over several hours, and that these changes occurred independently of activity. Intermittent stimulation for 1 h accelerated rates of vesicle pool size change. Interestingly, however, following stimulation cessation, vesicle pool size change rates gradually converged with basal change rates. Over similar time scales, active zones (AZs) exhibited substantial remodeling; yet, unlike synaptic vesicles, AZ remodeling was not affected by the stimulation paradigms used here. These findings indicate that enhanced activity levels can increase synaptic vesicle redistribution among nearby synapses, but also highlight the presence of forces that act to restore particular set points in terms of SV contents, and support a role for active zones in preserving such set points. These findings also indicate, however, that neither AZ size nor SV content set points are particularly stable, questioning the long-term tenacity of presynaptic specializations.
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Registered trials
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