ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Perinatal citalopram exposure selectively increases locus ceruleus circuit function in male rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Perinatal SSRI Exposure Disrupts G Protein-coupled Receptor BAI3 in Developing Dentate Gyrus and Adult Emotional Behavior: Relevance to Psychiatric Disorders.Neuroscience · 2021Article
- Anatomical Markers of Activity in Hypothalamic Neurons.Comprehensive Physiology · 2020Review
- Studying the Contribution of Serotonin to Neurodevelopmental Disorders. Can This Fly?Frontiers in behavioral neuroscience · 2020Review
- Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus.Cell reports · 2018Article
- Of rodents and humans: A comparative review of the neurobehavioral effects of early life SSRI exposure in preclinical and clinical research.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2016Review
- The Mechanisms Underlying the ASD Advantage in Visual Search.Journal of autism and developmental disorders · 2016Review
- Prenatal exposure to serotonin reuptake inhibitor antidepressants and childhood behavior.Pediatric research · 2015Article
- Behavioral training reverses global cortical network dysfunction induced by perinatal antidepressant exposure.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety/depression-prone rats.Neuroscience · 2015Article
- GABAB receptor-mediated tonic inhibition regulates the spontaneous firing of locus coeruleus neurons in developing rats and in citalopram-treated rats.The Journal of physiology · 2015Article
- Pupillometry reveals a mechanism for the Autism Spectrum Disorder (ASD) advantage in visual tasks.Scientific reports · 2014Article
- Cognitive impairments from developmental exposure to serotonergic drugs: citalopram and MDMA.The international journal of neuropsychopharmacology · 2013Article
- Central nervous system effects of prenatal selective serotonin reuptake inhibitors: sensing the signal through the noise.Psychopharmacology · 2013Review
- Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study.BMJ (Clinical research ed.) · 2013Article
- Neonatal citalopram exposure decreases serotonergic fiber density in the olfactory bulb of male but not female adult rats.Frontiers in cellular neuroscience · 2013Article
- Neonatal SSRI Exposure Programs a Hypermetabolic State in Adult Mice.Journal of nutrition and metabolism · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Selective serotonin reuptake inhibitors (SSRIs), such as citalopram (CTM), have been widely prescribed for major depressive disorder, not only for adult populations, but also for children and pregnant mothers. Recent evidence suggests that chronic SSRI exposure in adults increases serotonin (5-HT) levels in the raphe system and decreases norepinephrine (NE) locus ceruleus (LC) neural activity, suggesting a robust opposing interaction between these two monoamines. In contrast, perinatal SSRI exposure induces a long-lasting downregulation of the 5-HT-raphe system, which is opposite to that seen with chronic adult treatment. Therefore, the goal of the present investigation was to test the hypothesis that perinatal CTM exposure (20 mg/kg/d) from postnatal day 1 (PN1) to PN10 leads to hyperexcited NE-LC circuit function in adult rats (>PN90). Our single-neuron LC electrophysiological data demonstrated an increase in spontaneous and stimulus-driven neural activity, including an increase in phasic bursts in CTM-exposed animals. In addition, we demonstrated a corresponding immunoreactive increase in the rate-limiting catalyzing catecholamine enzyme (tyrosine hydroxylase) within the LC and their neocortical target sites compared to saline controls. Moreover, these effects were only evident in male exposed rats, suggesting a sexual dimorphism in neural development after SSRI exposure. Together, these results indicate that administration of SSRIs during a sensitive period of brain development results in long-lasting alterations in NE-LC circuit function in adults and may be useful in understanding the etiology of pervasive developmental disorders such as autism spectrum disorder.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.