ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
A seven-transmembrane receptor that mediates avoidance response to dihydrocaffeic acid, a water-soluble repellent in Caenorhabditis elegans.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Patterns of pathogenesis in innate immunity: insights from C. elegans.Nature reviews. Immunology · 2025Review
- Neurogrit Gold Attenuates 6-OHDA-Induced Dopaminergic Neurodegeneration in Parkinson's Model of Caenorhabditis elegans by Reducing α-Synuclein Accumulation and Pink/Pdr-1 Driven Mitochondrial Dysfunction.CNS neuroscience & therapeutics · 2025Article
- Article
- Dihydrocaffeic Acid-Is It the Less Known but Equally Valuable Phenolic Acid?Biomolecules · 2023Review
- Making "Sense" of Ecology from a Genetic Perspective:Metabolites · 2022Review
- Reduced CaFrontiers in neuroscience · 2022Article
- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- Transcriptomic analysis of hookworm Ancylostoma ceylanicum life cycle stages reveals changes in G-protein coupled receptor diversity associated with the onset of parasitism.International journal for parasitology · 2020Article
- Evolutionary plasticity in the innate immune function of Akirin.PLoS genetics · 2018Article
- An atlas of Caenorhabditis elegans chemoreceptor expression.PLoS biology · 2018Article
- Multisensory integration in C. elegans.Current opinion in neurobiology · 2017Review
- G protein-coupled receptors mediate neural regulation of innate immune responses inReceptors & clinical investigation · 2017Article
- Serotonin differentially modulates Ca2+ transients and depolarization in a C. elegans nociceptor.Journal of neurophysiology · 2015Article
- Breaking barriers: a GPCR triggers immunity in nematodes.Nature immunology · 2014Article
- Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans.Nature immunology · 2014Article
- The protein Ocular albinism 1 is the orphan GPCR GPR143 and mediates depressor and bradycardic responses to DOPA in the nucleus tractus solitarii.British journal of pharmacology · 2014Article
- The C. elegans cGMP-dependent protein kinase EGL-4 regulates nociceptive behavioral sensitivity.PLoS genetics · 2013Article
- Odour concentration-dependent olfactory preference change in C. elegans.Nature communications · 2012Article
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Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
Abstract
The ability to detect harmful chemicals rapidly is essential for the survival of all animals. In Caenorhabditis elegans (C. elegans), repellents trigger an avoidance response, causing animals to move away from repellents. Dihydrocaffeic acid (DHCA) is a water-soluble repellent and nonflavonoid catecholic compound that can be found in plant products. Using a Xenopus laevis (X. laevis) oocyte expression system, we identified a candidate dihydrocaffeic acid receptor (DCAR), DCAR-1. DCAR-1 is a novel seven-transmembrane protein that is expressed in the ASH avoidance sensory neurons of C. elegans. dcar-1 mutant animals are defective in avoidance response to DHCA, and cell-specific expression of dcar-1 in the ASH neurons of dcar-1 mutant animals rescued the defect in avoidance response to DHCA. Our findings identify DCAR-1 as the first seven-transmembrane receptor required for avoidance of a water-soluble repellent, DHCA, in C. elegans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.