ArticleJournal of neurophysiology2012
Gamma band activity in the developing parafascicular nucleus.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Differential effects of HDAC inhibitors on PPN oscillatory activity in vivo.Neuropharmacology · 2020Article
- Gamma oscillations in the pedunculopontine nucleus are regulated by F-actin: neuroepigenetic implications.American journal of physiology. Cell physiology · 2020Article
- Local and Relayed Effects of Deep Brain Stimulation of the Pedunculopontine Nucleus.Brain sciences · 2019Review
- Bottom-up gamma and bipolar disorder, clinical and neuroepigenetic implications.Bipolar disorders · 2019Review
- Class II histone deacetylases require P/Q-type CaScientific reports · 2018Article
- Arousal and drug abuse.Behavioural brain research · 2017Review
- Bottom-up gamma and stages of waking.Medical hypotheses · 2017Article
- Interaction between neuronal calcium sensor protein 1 and lithium in pedunculopontine neurons.Physiological reports · 2017Article
- DBS in Tourette syndrome: where are we standing now?Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Intracellular mechanisms modulating gamma band activity in the pedunculopontine nucleus (PPN).Physiological reports · 2016Article
- Lithium decreases the effects of neuronal calcium sensor protein 1 in pedunculopontine neurons.Physiological reports · 2016Article
- Bottom-up Gamma: the Pedunculopontine Nucleus and Reticular Activating System.Translational brain rhythmicity · 2016Article
- Pedunculopontine Gamma Band Activity and Development.Brain sciences · 2015Review
- High-threshold Ca2+ channels behind gamma band activity in the pedunculopontine nucleus (PPN).Physiological reports · 2015Article
- Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder.Journal of neurophysiology · 2015Article
- Gamma band activity in the RAS-intracellular mechanisms.Experimental brain research · 2014Review
- A major external source of cholinergic innervation of the striatum and nucleus accumbens originates in the brainstem.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Pedunculopontine Nucleus Gamma Band Activity-Preconscious Awareness, Waking, and REM Sleep.Frontiers in neurology · 2014Review
- Spatiotemporal properties of high-speed calcium oscillations in the pedunculopontine nucleus.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Visualization of fast calcium oscillations in the parafascicular nucleus.Pflugers Archiv : European journal of physiology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The parafascicular nucleus (Pf) receives cholinergic input from the pedunculopontine nucleus, part of the reticular activating system involved in waking and rapid eye movement (REM) sleep, and sends projections to the cortex. We tested the hypothesis that Pf neurons fire maximally at gamma band frequency (30-90 Hz), that this mechanism involves high-threshold voltage-dependent P/Q- and N-type calcium channels, and that this activity is enhanced by the cholinergic agonist carbachol (CAR). Patch-clamped 9- to 25-day-old rat Pf neurons (n = 299) manifested a firing frequency plateau at gamma band when maximally activated (31.5 ± 1.5 Hz) and showed gamma oscillations when voltage-clamped at holding potentials above -20 mV, and the frequency of the oscillations increased significantly with age (24.6 ± 3.8 vs. 51.6 ± 4.4 Hz, P < 0.001) but plateaued at gamma frequencies. Cells exposed to CAR showed significantly higher frequencies early in development compared with those without CAR (24.6 ± 3.8 vs. 41.7 ± 4.3 Hz, P < 0.001) but plateaued with age. The P/Q-type calcium channel blocker ω-agatoxin-IVA (ω-Aga) blocked gamma oscillations, whereas the N-type blocker ω-conotoxin-GVIA (ω-CgTx) only partially decreased the power spectrum amplitude of gamma oscillations. The blocking effect of ω-Aga on P/Q-type currents and ω-CgTx on N-type currents was consistent over age. We conclude that P/Q- and N-type calcium channels appear to mediate Pf gamma oscillations during development. We hypothesize that the cholinergic input to the Pf could activate these cells to oscillate at gamma frequency, and perhaps relay these rhythms to cortical areas, thus providing a stable high-frequency state for "nonspecific" thalamocortical processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.