ArticleJournal of clinical microbiology2012
It is time to use treponema-specific antibody screening tests for diagnosis of syphilis.
Article in Journal of clinical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- The Traditional or Reverse Algorithm for Diagnosis of Syphilis: Pros and Cons.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Pooled it
- Performance Assessment of Treponemal and Nontreponemal Tests for the Diagnosis of Acquired Syphilis.The American journal of tropical medicine and hygiene · 2024Article
- Article
- Article
- Assessment of recombinant antigens Tp0100 and Tp1016 of Treponema pallidum for serological diagnosis of syphilis.Journal of clinical laboratory analysis · 2022Article
- Analytical Performance Characteristics of a New Transcription-Mediated Amplification Assay for Treponema pallidum.Journal of clinical microbiology · 2021Article
- Nonviral sexually transmitted infections in pregnancy: current controversies and new challenges.Current opinion in infectious diseases · 2021Review
- Molecular and Direct Detection Tests for Treponema pallidum Subspecies pallidum: A Review of the Literature, 1964-2017.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Review
- Development of a syphilis serum bank to support research, development, and evaluation of syphilis diagnostic tests in the United States.Diagnostic microbiology and infectious disease · 2020Article
- Frequency and Characteristics of Biological False-Positive Test Results for Syphilis Reported in Florida and New York City, USA, 2013 to 2017.Journal of clinical microbiology · 2019Article
- Clinical Performance of the BioPlex 2200 Syphilis Total & RPR Assay at a Tertiary Medical Center with a High Rate of Syphilis.Journal of clinical microbiology · 2019Article
- Analytical Comparison of the Architect Syphilis TP and Liaison Treponema Automated Chemiluminescent Immunoassays and Their Performance in a Reverse Syphilis Screening Algorithm.Journal of clinical microbiology · 2018Article
- Development and Evaluation of a Loop-Mediated Isothermal Amplification Assay for the Detection ofThe American journal of tropical medicine and hygiene · 2017Article
- Comparison of Traditional and Reverse Syphilis Screening Algorithms in Medical Health Checkups.Annals of laboratory medicine · 2017Article
- Evaluation of the Lumipulse G TP-N Chemiluminescent Immunoassay as a Syphilis Screening Test.Journal of clinical microbiology · 2017Article
- Traditional versus reverse syphilis algorithms: A comparison at a large academic medical center.Practical laboratory medicine · 2017Article
- Review
- Comparison of automated treponemal and nontreponemal test algorithms as first-line syphilis screening assays.Annals of laboratory medicine · 2016Article
- Evaluation of a Rapid Immunochromatographic Treponemal Antibody Test Comparing the Treponema Pallidum Particle Agglutination Assay.Journal of clinical laboratory analysis · 2015Article
- Evaluation of the HISCL Anti-Treponema pallidum Assay as a Screening Test for Syphilis.Clinical and vaccine immunology : CVI · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Assays that detect treponema-specific antibodies, which are either automated or can be done as point-of-care tests, have been developed, some of which are FDA approved. These assays have the advantage of being easily performed and demonstrate high sensitivity, both key features of an infectious disease screening test. As a result, many high-volume clinical laboratories have begun to offer a reverse syphilis testing algorithm where a treponema-specific test is used for screening, followed by a nontreponemal test (i.e., rapid plasma reagin [RPR]) to assess disease activity and treatment status. Concerns about physicians being able to understand and apply this new testing algorithm have been expressed (8). In this point-counterpoint, Michael Loeffelholz of the University of Texas Medical Branch at Galveston explains why his laboratory has adopted this reverse algorithmic approach. Matthew Binnicker of the Mayo Clinic, Rochester, MN, explains why the reverse algorithm may not be suitable for all clinical laboratories and every clinical situation.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.