ArticleJournal of clinical microbiology2012
Prevalence and sequence variation of panton-valentine leukocidin in methicillin-resistant and methicillin-susceptible staphylococcus aureus strains in the United States.
Article in Journal of clinical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 74 citations in OpenAlex.
- A comparative analysis of the clinical and genomic characteristics of Panton-Valentine leukocidin-positive methicillin-resistantMicrobiology spectrum · 2026Article
- StaphSCAN: a genomic surveillance framework for Staphylococcus aureus.BMC genomics · 2026Article
- Predicted and inducible prophages display contrasting virulence gene profiles within the prophage-SaPI mobilome ofmSphere · 2026Article
- Development and validation of a hierarchical machine learning method using MALDI-TOF mass spectrometry for rapid SCCmec typing and PVL detection in MRSA: a multi-centre study.Emerging microbes & infections · 2025Article
- The Susceptibility Profiles of Human Peripheral Blood Cells toMicroorganisms · 2025Review
- The virulence toolkit of Staphylococcus aureus: a comprehensive review of toxin diversity, molecular mechanisms, and clinical implications.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Review
- The Relative Importance of Cytotoxins Produced by Methicillin-ResistantMicroorganisms · 2024Article
- Molecular and Phylogenomic Analysis of a Vancomycin Intermediate Resistance USA300LV Strain in Chile.Microorganisms · 2024Article
- Microbial keratitis in Southern Malawi: a microbiological pilot study.BMJ open ophthalmology · 2024Article
- Prevalence ofMicroorganisms · 2023Article
- Neutralization of the Staphylococcus aureus Panton-Valentine leukocidin by African and Caucasian sera.BMC microbiology · 2022Article
- Epidemiological and clinical features of Panton-Valentine Leukocidin positive Staphylococcus aureus bacteremia: A case-control study.PloS one · 2022Article
- Clonal diversity and genomic characterization of Panton-valentine Leukocidin (PVL)-positive Staphylococcus aureus in Tehran, Iran.BMC infectious diseases · 2021Article
- Skin infections due to Panton-Valentine leukocidin (PVL)-producing S. aureus-Cost effectiveness of outpatient treatment.PloS one · 2021Article
- Article
- Panton-Valentine leukocidin (PVL) isoforms among Staphylococcus aureus lineages isolated from hospitals in Rio de Janeiro, Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Time-resolved analysis ofVirulence · 2020Article
- Proteomics identifies a convergent innate response to infective endocarditis and extensive proteolysis in vegetation components.JCI insight · 2020Article
- Spontaneous community-acquired PVL-producing Staphylococcus aureus mediastinitis in an immunocompetent adult - a case report.BMC infectious diseases · 2020Article
- Hospital-Associated Multidrug-Resistant MRSA Lineages Are Trophic to the Ocular Surface and Cause Severe Microbial Keratitis.Frontiers in public health · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Panton-Valentine leukocidin (PVL), encoded by the lukSF-PV genes, is a putative virulence factor and marker for community-associated methicillin-resistant Staphylococcus aureus. Here we report the prevalence of PVL among a representative sample of 1,055 S. aureus infection isolates from the United States and describe the sequence variation of the lukSF-PV genes. We performed multilocus sequence typing (MLST) on all isolates and sequenced fragments of the lukSF-PV genes from a sample of 86 isolates. We assigned isolates to a PVL R or H sequence type based on a polymorphism that results in an amino acid change from arginine (R) to histidine (H). Overall, we found that 36% of S. aureus isolates were positive for lukSF-PV. Among the 86 we typed, we identified 72 R variants and 14 H variants. Among the 47 methicillin-resistance S. aureus (MRSA) isolates, 43 harbored the R variant, and among the 39 methicillin-susceptible S. aureus (MSSA) isolates, 29 harbored the R variant. Almost all (97%) of the R variants were found in MLST clonal complex 8 (CC8), while the H variant was broadly distributed among 6 CCs. Within CC8, all 38 MRSA (USA300) and all 28 MSSA isolates harbored the R variant. Of the 20 isolates from blood and the lower respiratory tract, 19 (95%) harbored the R variant. While the R variant had been linked primarily to USA300 MRSA, we found that all CC8 MSSA isolates also contained the R variant, suggesting that some strains of USA300 may have lost methicillin resistance as an adaptation in the community.
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