ArticleProceedings. Biological sciences2012
An ecological approach to assessing the epidemiology of antimicrobial resistance in animal and human populations.
Article in Proceedings. Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Genomic epidemiology of third-generation cephalosporin-resistantOne health (Amsterdam, Netherlands) · 2025Article
- Analysis ofMicrobial genomics · 2023Article
- Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America.Nature communications · 2022Article
- Changing food systems and infectious disease risks in low-income and middle-income countries.The Lancet. Planetary health · 2022Review
- Quantifying the Relationship between Antibiotic Use in Food-Producing Animals and Antibiotic Resistance in Humans.Antibiotics (Basel, Switzerland) · 2022Article
- Comparison of Antimicrobial-Resistant Escherichia coli Isolates from Urban Raccoons and Domestic Dogs.Applied and environmental microbiology · 2021Article
- Residual antimicrobial agents in food originating from animals.Trends in food science & technology · 2021Review
- Article
- High Prevalence and Diversity Characteristics ofFrontiers in cellular and infection microbiology · 2021Article
- Drivers of Antibiotic Resistance Transmissionin Low- and Middle-Income Countriesfrom a "One Health" Perspective-A Review.Antibiotics (Basel, Switzerland) · 2020Review
- Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania.Nature communications · 2020Article
- Antimicrobial Resistance in Swine Fecal Specimens Across Different Farm Management Systems.Frontiers in microbiology · 2020Article
- Article
- Clinically relevant antimicrobial resistance at the wildlife-livestock-human interface in Nairobi: an epidemiological study.The Lancet. Planetary health · 2019Article
- Antimicrobial Resistance Diversity Suggestive of DistinctFrontiers in microbiology · 2019Article
- Antibiotic Resistance inFrontiers in microbiology · 2019Article
- Human health implications of organic food and organic agriculture: a comprehensive review.Environmental health : a global access science source · 2017Review
- Whole-Genome Sequencing of Drug-Resistant Salmonella enterica Isolates from Dairy Cattle and Humans in New York and Washington States Reveals Source and Geographic Associations.Applied and environmental microbiology · 2017Article
- Genotype variation and genetic relationship among Escherichia coli from nursery pigs located in different pens in the same farm.BMC microbiology · 2017Article
- Antimicrobial resistance in human populations: challenges and opportunities.Global health, epidemiology and genomics · 2017Review
Corrections and comments
- Commented on by
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined long-term surveillance data on antimicrobial resistance (AMR) in Salmonella Typhimurium DT104 (DT104) isolates from concurrently sampled and sympatric human and animal populations in Scotland. Using novel ecological and epidemiological approaches to examine diversity, and phenotypic and temporal relatedness of the resistance profiles, we assessed the more probable source of resistance of these two populations. The ecological diversity of AMR phenotypes was significantly greater in human isolates than in animal isolates, at the resolution of both sample and population. Of 5200 isolates, there were 65 resistance phenotypes, 13 unique to animals, 30 unique to humans and 22 were common to both. Of these 22, 11 were identified first in the human isolates, whereas only five were identified first in the animal isolates. We conclude that, while ecologically connected, animals and humans have distinguishable DT104 communities, differing in prevalence, linkage and diversity. Furthermore, we infer that the sympatric animal population is unlikely to be the major source of resistance diversity for humans. This suggests that current policy emphasis on restricting antimicrobial use in domestic animals may be overly simplistic. While these conclusions pertain to DT104 in Scotland, this approach could be applied to AMR in other bacteria-host ecosystems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.