ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2012
Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- A Translational Review of Mechanisms of Effectiveness of Photobiomodulation on Somatosensory Neurons and the Peripheral Nervous System-From Molecular Mechanisms to Clinical Applications in Medicine and Dentistry.Current issues in molecular biology · 2026Review
- Junctional adhesion molecule-C: A multifunctional mediator of cell adhesion.Cellular and molecular life sciences : CMLS · 2025Review
- Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues.EMBO reports · 2024Article
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- Mechanisms Ensuring Endothelial Junction Integrity Beyond VE-Cadherin.Frontiers in physiology · 2020Review
- Heat stress-induced renal damage in poultry and the protective effects of HSP60 and HSP47.Cell stress & chaperones · 2018Article
- Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF.The Journal of experimental medicine · 2014Article
- JAM-related proteins in mucosal homeostasis and inflammation.Seminars in immunopathology · 2014Review
- Abnormal junctions and permeability of myelin in PMP22-deficient nerves.Annals of neurology · 2014Article
- Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Article
- The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats.Brain and behavior · 2012Article
- Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus.PloS one · 2012Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 3 countries.
Funding
Abstract
Junctional adhesion molecule-C (JAM-C) is an adhesion molecule expressed at junctions between adjacent endothelial and epithelial cells and implicated in multiple inflammatory and vascular responses. In addition, we recently reported on the expression of JAM-C in Schwann cells (SCs) and its importance for the integrity and function of peripheral nerves. To investigate the role of JAM-C in neuronal functions further, mice with a specific deletion of JAM-C in SCs (JAM-C SC KO) were generated. Compared to wild-type (WT) controls, JAM-C SC KO mice showed electrophysiological defects, muscular weakness, and hypersensitivity to mechanical stimuli. In addressing the underlying cause of these defects, nerves from JAM-C SC KO mice were found to have morphological defects in the paranodal region, exhibiting increased nodal length as compared to WTs. The study also reports on previously undetected expressions of JAM-C, namely on perineural cells, and in line with nociception defects of the JAM-C SC KO animals, on finely myelinated sensory nerve fibers. Collectively, the generation and characterization of JAM-C SC KO mice has provided unequivocal evidence for the involvement of SC JAM-C in the fine organization of peripheral nerves and in modulating multiple neuronal responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.