ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2012
Metabolic restriction of cancer cells in vitro causes karyotype contraction--an indicator of cancer promotion?
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines.Genes & diseases · 2025Article
- Explore association of genes in PDL1/PD1 pathway to radiotherapy survival benefit based on interaction model strategy.Radiation oncology (London, England) · 2021Article
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3 authors at 3 institutions in 2 countries.
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Abstract
The metabolism of cultured cancer cells is stimulated by 21% oxygen and generous nutrition, while real tumors grow in oxygen and nutrient-restricted environments. The effect of these contrasted conditions was studied in five hyperploid (54-69) cancer cell lines. When grown under anoxia and in the presence of antioxidant metabolic restrictors, the cell lines quickly reverted to almost normal chromosome numbers (47-49). The stepped withdrawal of oxygen over K562 showed progressive increases in proliferation rate and the acquisition of a stable, stem phenotype. In genetic studies, hyperploid cancer cells adjusted their chromosome numbers up or down to match their micro-environment through rapid mechanisms of endo-reduplication or chromosome loss. These fast reactions may explain the surprising adaptability of tumor cells to oncologic interventions. Furthermore, karyotype contraction may provide a basis for the previously observed carcinogenic influence of the administration of some antioxidants in human populations.
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