ArticleCirculation2012
Brugada-like syndrome in infancy presenting with rapid ventricular tachycardia and intraventricular conduction delay.
Article in Circulation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 70 citations in OpenAlex.
- Enhanced risk profiling of implanted defibrillator shocks with circulating SCN5A mRNA splicing variants: a pilot trial.Journal of the American College of Cardiology · 2014Trial
- Functional Profiling ofCirculation. Genomic and precision medicine · 2025Article
- AHeartRhythm case reports · 2025Article
- Congenital Complete Heart Block-To Stimulate (When?) or Not to Stimulate?Healthcare (Basel, Switzerland) · 2024Article
- Review
- Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts.Nature communications · 2022Article
- J wave syndromes: What's new?Trends in cardiovascular medicine · 2022Review
- J wave syndromes as a cause of malignant cardiac arrhythmias.Pacing and clinical electrophysiology : PACE · 2018Review
- Recent advances in the treatment of Brugada syndrome.Expert review of cardiovascular therapy · 2018Review
- Mutations in voltage-gated L-type calcium channel: implications in cardiac arrhythmia.Channels (Austin, Tex.) · 2018Review
- Ajmaline-Induced Slowing of Conduction in the Right Ventricular Outflow Tract Cannot Account for ST Elevation in Patients With Type I Brugada ECG.Circulation. Arrhythmia and electrophysiology · 2017Article
- J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2017Review
- J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge.Journal of arrhythmia · 2016Article
- J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge.Heart rhythm · 2016Review
- Congenital and childhood atrioventricular blocks: pathophysiology and contemporary management.European journal of pediatrics · 2016Review
- A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias.Journal of molecular and cellular cardiology · 2016Article
- [Brugada ECG].Herzschrittmachertherapie & Elektrophysiologie · 2015Article
- J-wave syndromes: Brugada and early repolarization syndromes.Heart rhythm · 2015Review
- A pediatric case of Brugada syndrome diagnosed by fever-provoked ventricular tachycardia.Korean journal of pediatrics · 2014Article
- A novel rare variant in SCN1Bb linked to Brugada syndrome and SIDS by combined modulation of Na(v)1.5 and K(v)4.3 channel currents.Heart rhythm · 2012Article
Corrections and comments
- Commented on by
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBrugada syndrome is a potentially serious channelopathy that usually presents in adulthood and has only rarely been described in infancy. In the absence of metabolic or structural cardiac disease, rapid ventricular tachycardia (>200 bpm) and primary cardiac conduction disease are uncommon in infancy. We hypothesized that infants having rapid ventricular tachycardia and conduction abnormalities and not having structural or metabolic pathogeneses were likely to have mutations in depolarizing current channels. METHODS AND
resultsA retrospective review of all clinical materials from a single institution over a 9-year period from all infants <2 years old and having a discharge diagnosis of ventricular tachycardia or ventricular fibrillation was performed. Among 32 infants fulfilling inclusion criteria, 12 had a structurally normal heart, and 9 of them had either prolonged QRS duration or Brugada pattern while in sinus rhythm. Of those 5 infants not having a definitive pathogenesis, electrophysiological testing had been performed in 4, and genetic testing had been performed in all 5 of those infants. During electrophysiological testing, a prolonged HV interval was present in 2 of 4, inducible ventricular tachycardia was present in 1 of 4, and a type 1 Brugada pattern was induced by intravenous procainamide in 3 of 4. Genetic testing revealed disease-causing mutations in depolarizing sodium (SCN5A) or calcium (CaCNB2b) channels in all 5 infants.
conclusionsInfants having rapid ventricular tachycardia and conduction abnormalities in the absence of structural or metabolic abnormalities are likely to have disease-causing mutations in cardiac depolarizing channels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.