ArticleJournal of virology2012
The V protein of mumps virus plays a critical role in pathogenesis.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- A Chimeric Virus Approach Reveals the Matrix (M) Gene as a Critical Modulator of Mumps Virus Neurovirulence.Vaccines · 2026Article
- Mumps Virus: Replication, Immune Response, and the Changing Landscape of Vaccine Effectiveness.Pathogens (Basel, Switzerland) · 2026Review
- Mumps virus infection triggers early pro-inflammatory responses and impairs Leydig and Sertoli cell function in an ex vivo human testis model.Human reproduction (Oxford, England) · 2025Article
- A region of mumps virus nucleoprotein affects defective interfering particle production.The Journal of general virology · 2025Article
- Exploration of microRNAs as transcriptional regulator in mumps virus infection through computational studies.Scientific reports · 2024Article
- Immunogenicity of Mumps Virus Genotype G Vaccine Candidates in Jeryl Lynn-Immunized Mice.Journal of virology · 2022Article
- A Highly Attenuated Mumps Virus Strain of Genotype F Generated by Passaging in Vero Cells.Virologica Sinica · 2021Article
- Regulation of Mumps Virus Replication and Transcription by Kinase RPS6KB1.Journal of virology · 2020Article
- A Single Point Mutation in the Mumps V Protein Alters Targeting of the Cellular STAT Pathways Resulting in Virus Attenuation.Viruses · 2019Article
- Attenuated MuV-S79 as vector stably expressing foreign gene.World journal of pediatrics : WJP · 2019Article
- Article
- Mass spectrometry-based investigation of measles and mumps virus proteome.Virology journal · 2018Article
- Immunogenicity of mumps virus vaccine candidates matching circulating genotypes in the United States and China.Vaccine · 2017Article
- Establishing a small animal model for evaluating protective immunity against mumps virus.PloS one · 2017Article
- Mumps virus pathogenesis: Insights and knowledge gaps.Human vaccines & immunotherapeutics · 2016Article
- Mumps Virus Nucleoprotein Enhances Phosphorylation of the Phosphoprotein by Polo-Like Kinase 1.Journal of virology · 2016Article
- Recombinant mumps virus as a cancer therapeutic agent.Molecular therapy oncolytics · 2016Article
- Regulation of Viral RNA Synthesis by the V Protein of Parainfluenza Virus 5.Journal of virology · 2015Article
- Oligomerization of Mumps Virus Phosphoprotein.Journal of virology · 2015Article
- Roles of Phosphorylation of the Nucleocapsid Protein of Mumps Virus in Regulating Viral RNA Transcription and Replication.Journal of virology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Mumps virus (MuV) causes an acute infection in humans characterized by a wide array of symptoms ranging from relatively mild manifestations, such as parotitis, to more-severe complications, such as meningitis and encephalitis. Widespread mumps vaccination has reduced mumps incidence dramatically; however, outbreaks still occur in vaccinated populations. The V protein of MuV, when expressed in cell culture, blocks interferon (IFN) expression and signaling and interleukin-6 (IL-6) signaling. In this work, we generated a recombinant MuV incapable of expressing the V protein (rMuVΔV). The rescued MuV was derived from a clinical wild-type isolate from a recent outbreak in the United States (MuV(Iowa/US/06), G genotype). Analysis of the virus confirmed the roles of V protein in blocking IFN expression and signaling and IL-6 signaling. We also found that the rMuV(Iowa/US/06)ΔV virus induced high levels of IL-6 expression in vitro, suggesting that V plays a role in reducing IL-6 expression. In vivo, the rMuV(Iowa/US/06)ΔV virus was highly attenuated, indicating that the V protein plays an essential role in viral virulence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.