ArticleJournal of virology2012
Genetic informational RNA is not required for recombinant prion infectivity.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 45 citations in OpenAlex.
- The octapeptide repeats of prion protein play critical roles in the pathogenesis of prion diseases.Acta neuropathologica communications · 2026Article
- Essential Components of Synthetic Infectious Prion Formation De Novo.Biomolecules · 2022Review
- Review
- Mice Treated Subcutaneously with Mouse LPS-Converted PrPVeterinary sciences · 2021Article
- Efficient interspecies transmission of synthetic prions.PLoS pathogens · 2021Article
- Aldehyde Production as a Calibrant of Ultrasonic Power Delivery During Protein Misfolding Cyclic Amplification.The protein journal · 2020Article
- A complete catalog of wild-type Sup35 prion variants and their protein-only propagation.Current genetics · 2020Article
- Prion infectivity is encoded exclusively within the structure of proteinase K-resistant fragments of synthetically generated recombinant PrPActa neuropathologica communications · 2018Article
- Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies.Cold Spring Harbor perspectives in medicine · 2017Review
- Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity.PLoS pathogens · 2017Article
- The role of the unusual threonine string in the conversion of prion protein.Scientific reports · 2016Article
- Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease.Brain research · 2016Review
- Prions: Beyond a Single Protein.Clinical microbiology reviews · 2016Review
- Insights into Mechanisms of Chronic Neurodegeneration.International journal of molecular sciences · 2016Review
- Intraperitoneal Infection of Wild-Type Mice with Synthetically Generated Mammalian Prion.PLoS pathogens · 2015Article
- G-quadruplexes within prion mRNA: the missing link in prion disease?Nucleic acids research · 2014Article
- Prion disease and the 'protein-only hypothesis'.Essays in biochemistry · 2014Review
- Infrared microspectroscopy detects protein misfolding cyclic amplification (PMCA)-induced conformational alterations in hamster scrapie progeny seeds.The Journal of biological chemistry · 2013Article
- De novo generation of infectious prions with bacterially expressed recombinant prion protein.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Whether a genetic informational nucleic acid is required for the infectivity of transmissible spongiform encephalopathies is central to the debate about the infectious agent. Here we report that an infectious prion formed with bacterially expressed recombinant prion protein plus synthetic polyriboadenylic acid and synthetic phospholipid 1-palmitoyl-2-oleoylphosphatidylglycerol is competent to infect cultured cells and cause prion disease in wild-type mice. Our results show that genetic informational RNA is not required for recombinant prion infectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.