SynthesisJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2012
Volume-outcome relationship in surgery for esophageal malignancy: systematic review and meta-analysis 2000-2011.
Synthesis in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
115 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Impact of pulmonary complications following esophagectomy on long-term survival: multivariate meta-analysis and restricted mean survival time assessment.Updates in surgery · 2024Pooled it
- Consensus statement of the Hellenic and Cypriot Oesophageal Cancer Study Group on the diagnosis, staging and management of oesophageal cancer.Updates in surgery · 2019Guideline
- Pooled it
- Neoadjuvant chemoradiotherapy or chemotherapy for gastroesophageal junction adenocarcinoma: A systematic review and meta-analysis.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2019Pooled it
- [Impact of perioperative nutritional therapy on risk and complication management in patients undergoing esophagectomy for cancer].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2016Pooled it
- Multimodality treatment for esophageal adenocarcinoma: multi-center propensity-score matched study.Annals of oncology : official journal of the European Society for Medical Oncology · 2017Trial
- Trial
- Institutional enrollment volume and clinical outcomes after surgery or chemoradiotherapy for clinical stage I esophageal squamous cell carcinoma: a supplementary analysis of JCOG0502.Esophagus : official journal of the Japan Esophageal Society · 2026Article
- Learning curve-associated safety in minimally invasive esophagectomy using a time-based supervisory takeover strategy: a propensity score-weighted analysis of 603 VATS procedures.Surgical endoscopy · 2026Article
- Simulation study on the regionalization of esophagectomy using data from 27,476 patients in Japan.Esophagus : official journal of the Japan Esophageal Society · 2026Article
- Impact of hospital volume on outcomes of esophagectomy for esophageal cancer: analysis of a prospective multicenter database.Surgical endoscopy · 2026Article
- Case Report: a Single-Patient Experience with Trans-Sphincteric Esophagojejunostomy for Concurrent Achalasia and Morbid Obesity.Obesity surgery · 2026Article
- Development and Validation of EsoTIME, a Prognostication Tool for Resected Esophageal and Gastroesophageal Cancer.Annals of surgical oncology · 2026Article
- Article
- Influence of Facility Size on Perioperative Outcomes in Minimally Invasive Esophagectomy for 14 152 Patients With Esophageal Cancer Based on the Japanese National Clinical Database: A Multicenter Cohort Study.Annals of gastroenterological surgery · 2025Article
- McKeown minimally invasive esophagectomy under discontinuous spontaneous ventilating anesthesia by laryngeal mask: a retrospective non-inferiority cohort study.Journal of thoracic disease · 2025Article
- Outcomes after radical endoscopic resection of high risk T1 esophageal adenocarcinoma: an international multicenter retrospective cohort study.Endoscopy · 2025Article
- Outcomes of Salvage Surgery for Esophageal Carcinoma: A Nationwide Cohort Study from the Dutch Upper GI Cancer Audit.Annals of surgical oncology · 2025Article
- ASO Author Reflections: Insights in Salvage Surgery for Esophageal Carcinoma.Annals of surgical oncology · 2025Article
- Summary of the ROMIO randomized-control trial comparing clinical, economic and patient-reported outcomes between open versus hybrid esophagectomy in the United Kingdom.Journal of thoracic disease · 2025Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study is to provide a contemporary quantitative analysis of the existing literature examining the relationship between surgical caseload and outcome following esophageal resection.
methodsMedline, Embase, trial registries, conference proceedings and reference lists were searched for trials comparing clinical outcome following esophagectomy from high- and low-volume hospitals since 2000. Primary outcomes were in-hospital and 30-day mortality. Secondary outcomes were length of hospital stay and post-operative complications.
resultsNine appropriate publications comprising 27,843 esophagectomy operations were included, 12,130 and 15,713 operations were performed in low- and high-volume surgical units, respectively. Esophagectomy at low-volume hospitals was associated with a significant increase in incidence of in-hospital (8.48% vs. 2.82%; pooled odds ratio (POR) = 0.29; P < 0.0001) and 30-day mortality (2.09% vs. 0.73%; POR = 0.31; P < 0.0001). There was insufficient data for conclusive statistical analysis of length of hospital stay or post-operative complications.
conclusionsThis meta-analysis does suggest a benefit in the centralization of esophageal cancer surgery to high-volume institutions with respect to mortality. The outcomes of this study are of interest to patients, healthcare providers and payers, particularly regarding service reconfiguration and more specifically centralization of services. Future studies that look at long-term survival will help improve understanding of any late consequences such as survival and quality of life following esophageal surgery at low- and high-volume hospitals.
Indexed as
Identifiers
22089950What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.