ArticleThe American naturalist2011
Causes of variation in malaria infection dynamics: insights from theory and data.
Article in The American naturalist, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Malaria parasites can optimize transmission investment by sensing two within-host cues.PLoS biology · 2025Article
- Dynamics of parasite growth in genetically diverse Plasmodium falciparum isolates.Molecular and biochemical parasitology · 2023Article
- Article
- Differential drivers of intraspecific and interspecific competition during malaria-helminth co-infection.Parasitology · 2021Article
- Uncovering drivers of dose-dependence and individual variation in malaria infection outcomes.PLoS computational biology · 2020Article
- Plasticity and genetic variation in traits underpinning asexual replication of the rodent malaria parasite, Plasmodium chabaudi.Malaria journal · 2019Article
- Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence.Nature communications · 2018Article
- What Controls the Acute Viral Infection Following Yellow Fever Vaccination?Bulletin of mathematical biology · 2018Article
- A nutrient mediates intraspecific competition between rodent malaria parasitesProceedings. Biological sciences · 2017Article
- Combining laboratory and mathematical models to infer mechanisms underlying kinetic changes in macrophage susceptibility to an RNA virus.BMC systems biology · 2016Article
- Predicting optimal transmission investment in malaria parasites.Evolution; international journal of organic evolution · 2016Article
- Review
- Understanding genetic variation in in vivo tolerance to artesunate: implications for treatment efficacy and resistance monitoring.Evolutionary applications · 2015Article
- Disentangling the interaction among host resources, the immune system and pathogens.Ecology letters · 2014Article
- Immune-mediated competition in rodent malaria is most likely caused by induced changes in innate immune clearance of merozoites.PLoS computational biology · 2014Article
- Modelling the dynamics of an experimental host-pathogen microcosm within a hierarchical Bayesian framework.PloS one · 2013Article
- A multi-scale analysis of influenza A virus fitness trade-offs due to temperature-dependent virus persistence.PLoS computational biology · 2013Article
- Revealing mechanisms underlying variation in malaria virulence: effective propagation and host control of uninfected red blood cell supply.Journal of the Royal Society, Interface · 2012Article
- The problem of auto-correlation in parasitology.PLoS pathogens · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Parasite strategies for exploiting host resources are key determinants of disease severity (i.e., virulence) and infectiousness (i.e., transmission between hosts). By iterating the development of theory and empirical tests, we investigated whether variation in parasite traits across two genetically distinct clones of the rodent malaria parasite, Plasmodium chabaudi, explains differences in within-host infection dynamics and virulence. First, we experimentally tested key predictions of our earlier modeling work. As predicted, the more virulent genotype produced more progeny parasites per infected cell (burst size), but in contrast to predictions, invasion rates of red blood cells (RBCs) did not differ between the genotypes studied. Second, we further developed theory by confronting our earlier model with these new data, testing a new set of models that incorporate more biological realism, and developing novel theoretical tools for identifying differences between parasite genotypes. Overall, we found robust evidence that differences in burst sizes contribute to variation in dynamics and that differential interactions between parasites and host immune responses also play a role. In contrast to previous work, our model predicts that RBC age structure is not important for explaining dynamics. Integrating theory and empirical tests is a potentially powerful way of progressing understanding of disease biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.