Evidence map›Paper›PMID 22089812›Full record

ReviewPflugers Archiv : European journal of physiology2012

Physiology of potassium channels in the inner membrane of mitochondria.

Ildikò Szabò, Luigi Leanza, Erich Gulbins, Mario Zoratti

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pflugers Archiv : European journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 75 citations in OpenAlex.

  1. Metabolic Shades of S-D-Lactoylglutathione.Antioxidants (Basel, Switzerland) · 2022
    Review
  2. Article
  3. Mitochondrial HAnnual review of physiology · 2022
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Pharmacological modulation of mitochondrial ion channels.British journal of pharmacology · 2019
    Review
  13. Article
  14. Targeting Mitochondrial Ion Channels to Fight Cancer.International journal of molecular sciences · 2018
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. A highly selective mitochondria-targeting fluorescent K(+) sensor.Angewandte Chemie (International ed. in English) · 2015
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Ildikò SzabòDepartment of Biology, University of Padova, Padova, Italy. ildiko.szabo@unipd.it
Luigi Leanza
Erich Gulbins
Mario Zoratti
University of Padua · ITNeuroscience Institute · ITUniversity of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inner membrane of the ATP-producing organelles of endosymbiotic origin, mitochondria, has long been considered to be poorly permeable to cations and anions, since the strict control of inner mitochondrial membrane permeability is crucial for efficient ATP synthesis. Over the past 30 years, however, it has become clear that various ion channels--along with antiporters and uniporters--are present in the mitochondrial inner membrane, although at rather low abundance. These channels are important for energy supply, and some are a decisive factor in determining whether a cell lives or dies. Their electrophysiological and pharmacological characterisations have contributed importantly to the ongoing elucidation of their pathophysiological roles. This review gives an overview of recent advances in our understanding of the functions of the mitochondrial potassium channels identified so far. Open issues concerning the possible molecular entities giving rise to the observed activities and channel protein targeting to mitochondria are also discussed.

Indexed as

Adenosine TriphosphateAnimalsEnergy MetabolismHumansMitochondrial MembranesPotassiumPotassium ChannelsAdenosine TriphosphatePotassiumPotassium Channels

Identifiers

PMID22089812
OpenAlexW2009649075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.