ReviewThe Indian journal of medical research2011
Hb E/beta-thalassaemia: a common & clinically diverse disorder.
Review in The Indian journal of medical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Hydroxyurea for hemoglobin E/β-thalassemia: a systematic review and meta-analysis.International journal of hematology · 2017Pooled it
- Plasma microRNA-451 as a novel hemolytic marker for β0-thalassemia/HbE disease.Molecular medicine reports · 2017Trial
- Genetic Mutations and Clinical Severity in Hemoglobin E/Beta-Thalassemia Patients in Bangladesh.Cureus · 2026Article
- Prevalence of Severe Thalassemia and Performance of Prenatal Screening Tests Among Pregnant Women at Siriraj Thalassemia Center in Thailand.Clinical and translational science · 2026Article
- Article
- Novel HBB:c.375_376delAC mutation in a Malay patient with HbE beta-thalassemia intermedia: A case report.Medicine · 2025Article
- Risk Stratification-Based Therapy for Children with E-beta Thalassemia: A 20-Year Follow-Up Study.Indian pediatrics · 2025Article
- Assessment of Lung Function and Its Correlation With Iron Overload in Children With Thalassemia Major.Cureus · 2025Article
- Article
- Predisposing Factors to Infections in Thalassemia Syndrome Patients.Mediterranean journal of hematology and infectious diseases · 2025Article
- Prevalence of dental caries, oral health status, malocclusion status, and dental treatment needs in thalassemic children: A cross-sectional study.Journal of family medicine and primary care · 2024Article
- Genetic modifications ofHeliyon · 2024Article
- Detection of HbD Punjab Trait in Saurashtra Region of Gujarat by HPLC Method.Indian journal of clinical biochemistry : IJCB · 2024Article
- An incidental finding of a hemoglobin E variant in a diabetic patient with an abnormal glycated hemoglobin level: a case report.Journal of medical case reports · 2024Article
- Global Trends on β-Thalassemia Research Over 10 Years: A Bibliometric Analysis.International journal of general medicine · 2024Article
- The Characteristics of Compound Heterozygosity for Hemoglobin G-Makassar with Hb E in Malaysia.Journal of blood medicine · 2024Article
- HBB Gene Mutations and Their Pathological Impacts on HbE/β-Thalassaemia in Kuala Terengganu, Malaysia.Diagnostics (Basel, Switzerland) · 2023Article
- Therapeutic adenine base editing of human hematopoietic stem cells.Nature communications · 2023Article
- A Case of Anaemia With High-Grade Splenomegaly.Cureus · 2022Article
- Activation of STAT and SMAD Signaling Induces Hepcidin Re-Expression as a Therapeutic Target for β-Thalassemia Patients.Biomedicines · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haemoglobin E-beta thalassaemia (Hb E/β-thalassaemia) is the genotype responsible for approximately one-half of all severe beta-thalassaemia worldwide. The disorder is characterized by marked clinical variability, ranging from a mild and asymptomatic anaemia to a life-threatening disorder requiring transfusions from infancy. The phenotypic variability of Hb E/β-thalassaemia and the paucity of long-term clinical data, present challenges in providing definitive recommendations for the optimal management of patients. Genetic factors influencing the severity of this disorder include the type of beta-thalassaemia mutation, the co-inheritance of alpha-thalassaemia, and polymorphisms associated with increased production of foetal haemoglobin. Other factors, including a variable increase in serum erythropoietin in response to anaemia, previous or ongoing infection with malaria, previous splenectomy and other environmental influences, may be involved. The remarkable variation, and the instability, of the clinical phenotype of Hb E beta-thalassaemia suggests that careful tailoring of treatment is required for each patient, and that therapeutic approaches should be re-assessed over-time.
Indexed as
Identifiers
22089616PMC3237252W2104994791What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.