SynthesisInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.
Synthesis in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: an updated meta-analysis.Zeitschrift fur Rheumatologie · 2019Pooled it
- Association of Interleukin-23 receptor gene polymorphisms with susceptibility to Crohn's disease: A meta-analysis.Scientific reports · 2015Pooled it
- Association of interleukin 23 receptor gene polymorphisms (rs10489629, rs7517847) with rheumatoid arthritis in European population: a meta-analysis.Molecular biology reports · 2012Pooled it
- The Genetic Background of Ankylosing Spondylitis Reveals a Distinct Overlap with Autoimmune Diseases: A Systematic Review.Journal of clinical medicine · 2025Review
- Evaluation of the mTORC activity in the presence of Toxoplasma gondii and azathioprine in human monocyte cell line.BMC microbiology · 2023Article
- Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis.BMC medical genetics · 2018Article
- Article
- Bone as a Target Organ in Rheumatic Disease: Impact on Osteoclasts and Osteoblasts.Clinical reviews in allergy & immunology · 2016Review
- Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications.World journal of orthopedics · 2014Review
- rs10865331 associated with susceptibility and disease severity of ankylosing spondylitis in a Taiwanese population.PloS one · 2014Article
- Lack of associations between two previously identified susceptible single nucleotide polymorphisms of interleukin-23 receptor gene and ankylosing spondylitis: a replication study in a Chinese Han population.BMC musculoskeletal disorders · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to determine whether interleukin-23R (IL-23R) polymorphisms confer susceptibility to ankylosing spondylitis (AS).
methodsThe authors conducted meta-analyses on associations between IL-23R polymorphisms and AS susceptibility, using fixed and random effects models.
resultsA total of 10 studies (14 separate comparisons) were included in this meta-analysis, which included European and Asian populations. Meta-analysis revealed a significant association between AS and the two alleles of rs11209032 polymorphism in all study subjects (OR = 1.182, 95% CI 1.120-1.249, P = 0.000). Stratification by ethnicity identified a significant association between this polymorphism and AS in the European (OR = 1.234, 95% CI 1.159-1.313, P = 0.000), but not in the Asian populations (OR = 1.030, 95% CI 0.921-1.152, P = 0.608). Meta-analyses of rs1004819, rs10489629, rs1343151, rs1495965, and rs2201841 polymorphisms showed the same pattern as that shown by rs11209032 meta-analysis. Meta-analysis also revealed a significant association between the two alleles of the rs11209026 and the rs11465804 polymorphisms and the risk of developing AS in Europeans. Interestingly, the rs7517847 polymorphism was found to be significantly associated with AS susceptibility in both Europeans and Asians.
conclusionsThis meta-analysis shows that the IL-23R polymorphisms are associated with the development of AS in Europeans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.