ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2012
Quantitative tract-specific measures of uncinate and cingulum in major depression using diffusion tensor imaging.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 4 of them syntheses that pooled it.
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Who cites it
68 citing papers in PubMed, 4 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- The association between white matter hyperintensities and suicide attempts in affective disorders: a systematic review and meta-analysis.Translational psychiatry · 2025Pooled it
- Early life adversity and white matter microstructural organization-a systematic review.Brain imaging and behavior · 2025Pooled it
- Microstructural white matter alterations associated with migraine headaches: a systematic review of diffusion tensor imaging studies.Brain imaging and behavior · 2022Pooled it
- Shared white matter alterations across emotional disorders: A voxel-based meta-analysis of fractional anisotropy.NeuroImage. Clinical · 2016Pooled it
- Enhancing depression diagnosis with augmented brain signal driven decorrelated graph neural networks.Communications medicine · 2026Article
- The Effect of Forkhead Box O1 Single Nucleotide Polymorphisms on Cortical Thickness and White Matter Integrity in High Suicide Risk Patients.Psychiatry investigation · 2024Article
- Plasma Apo-E mediated corticospinal tract abnormalities and suicidality in patients with major depressive disorder.European archives of psychiatry and clinical neuroscience · 2024Article
- White Matter Function and Network Abnormalities in Patients with Diabetic Retinopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Pathophysiology in cortico-amygdala circuits and excessive aversion processing: the role of oligodendrocytes and myelination.Brain communications · 2024Review
- Article
- Structural and functional differences in the brains of patients with MCI with and without depressive symptoms and their relations with Alzheimer's disease: an MRI study.Psychoradiology · 2023Article
- White matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions.Depression and anxiety · 2022Article
- Personalized Diagnosis and Treatment for Neuroimaging in Depressive Disorders.Journal of personalized medicine · 2022Review
- Immature excitatory neurons in the amygdala come of age during puberty.Developmental cognitive neuroscience · 2022Article
- Individual variation in white matter microstructure is related to better recovery from negative stimuli.Emotion (Washington, D.C.) · 2022Article
- White Matter Tracts Associated With Deep Brain Stimulation Targets in Major Depressive Disorder: A Systematic Review.Frontiers in psychiatry · 2022Review
- Computational reinforcement learning, reward (and punishment), and dopamine in psychiatric disorders.Frontiers in psychiatry · 2022Review
- Mindfulness-Based Cognitive Therapy Regulates Brain Connectivity in Patients With Late-Life Depression.Frontiers in psychiatry · 2022Article
- Multimodal brain imaging connectivity analyses of emotional and motivational deficits in depression among women.Journal of psychiatry & neuroscience : JPN · 2021Article
- Age-related differences in structural and functional prefrontal networks during a logical reasoning task.Brain imaging and behavior · 2021Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Previous findings suggested the role of the prefrontal cortex, hippocampus, and cingulate gyrus in major depressive disorders (MDD), but the white matter microstructural abnormalities of the fibers connecting these brain structures are not known. The purpose of this study was to test the hypothesis that white matter abnormalities are present in association fibers of the uncinate fasciculus (UF) and cingulum bundle (CB) among MDD subjects. A total of 21 MDD subjects aged between 30 and 65 years and 21 age-matched healthy controls (HC) were recruited. All subjects were right-handed and without history of diabetes or other cardiac diseases. We extracted quantitative tract-specific measures based on diffusion tensor imaging tractography to examine both diffusivity and geometric properties of the UF and CB. Significantly decreased fractional anisotropy (FA) and increased radial diffusivity of the right UF were observed in MDD patients compared with HC (p<0.05), while their geometric characteristics remained relatively unchanged. Among MDD subjects, depression severity had a significant negative correlation with normalized number of fibers (NNF) in the right UF (r=-0.53, p=0.02). We also found significant age effect (old<young) in HC group and laterality effect (L>R) in both groups in the FA measure of the CB. Our study demonstrates novel findings of white matter microstructural abnormalities of the right UF in MDD. In the MDD group, the severity of depression is associated with reduced NNF in the right UF. These findings have implications for both clinical manifestations of depression as well as its pathophysiology.
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