ArticleJournal of assisted reproduction and genetics2012
Aqueous extract of Azadirachta indica (neem) leaf induces generation of reactive oxygen species and mitochondria-mediated apoptosis in rat oocytes.
Article in Journal of assisted reproduction and genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Honghua Xiaoyao tablet combined with estradiol improves ovarian function in D-galactose-induced aging mice by reducing apoptosis and affecting the release of reproductive hormones: anFrontiers in pharmacology · 2024Article
- Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Review
- Autophagy in hypoxic ovary.Cellular and molecular life sciences : CMLS · 2019Review
- Necroptosis in stressed ovary.Journal of biomedical science · 2019Review
- Germ cell depletion from mammalian ovary: possible involvement of apoptosis and autophagy.Journal of biomedical science · 2018Review
- Effect of aqueous extract of Azadirachta indica A. Juss (neem) leaf on oocyte maturation, oviposition, reproductive potentials and embryonic development of a freshwater fish ectoparasite Argulus bengalensis Ramakrishna, 1951 (Crustacea: Branchiura).Parasitology research · 2014Article
- Neem components as potential agents for cancer prevention and treatment.Biochimica et biophysica acta · 2014Review
- Neem (Azadirachta indica L.) leaf extract deteriorates oocyte quality by inducing ROS-mediated apoptosis in mammals.SpringerPlus · 2014Review
- Haemolytic anaemia after ingestion of Neem (Azadirachta indica) tea.BMJ case reports · 2013Article
- An increase of granulosa cell apoptosis mediates aqueous neem (Azadirachta indica) leaf extract-induced oocyte apoptosis in rat.International journal of applied & basic medical research · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePresent study was aimed to determine whether aqueous neem leaf extract (NLE) induces generation of reactive oxygen species (ROS) and apoptosis through mitochondria-mediated pathway in rat oocytes.
designA controlled prospective study.
settingLaboratory research setting at Department of Zoology of Banaras Hindu University. ANIMAL(S): Forty eight sexually immature female rats that were 20-30 days of age. INTERVENTION(S): Sexually immature female rats were fed palatable dose of NLE (10 mg/g dry feed palate) for 10 days and then subjected to superovulation induction protocol. Thereafter, rats were euthanized, ovulated cumulus oocyte complexes were collected from oviduct and oocytes were denuded. MAIN OUTCOME MEASURE(S): Rate of morphological apoptotic changes, measurement of hydrogen peroxide, nitric oxide and cytochrome c concentrations, caspase-9, caspases-3 activities and DNA fragmentation in oocytes.
resultsIn vivo NLE treatment induced morphological apoptotic changes were associated with increased hydrogen peroxide, nitric oxide and cytochrome c concentrations, caspase-9, caspase-3 activities and DNA fragmentation in oocyte.
conclusionNLE induces generation of ROS that leads to oocytes apoptosis through mitochondria-mediated pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.