ArticleCornea2011
Comparison of mucin levels at the ocular surface of postmenopausal women with and without a history of dry eye.
Article in Cornea, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 64 citations in OpenAlex.
- Comparison of tear proteomic and neuromediator profiles changes between small incision lenticule extraction (SMILE) and femtosecond laser-assisted in-situ keratomileusis (LASIK).Journal of advanced research · 2021Trial
- Ocular surface glycocalyx in health and disease.Frontiers in cell and developmental biology · 2025Review
- Predicting Risks of Dry Eye Disease Development Using a Genome-Wide Polygenic Risk Score Model.Translational vision science & technology · 2024Article
- Regional Conjunctival Differences in Glycocalyx Mucin Expression in Dry Eye and Normal Subjects.Investigative ophthalmology & visual science · 2024Article
- Comparison of mucin levels at the ocular surface of visual display terminal users with and without dry eye disease.BMC ophthalmology · 2023Article
- Proteomic Profiling of Saliva and Tears in Radiated Head and Neck Cancer Patients as Compared to Primary Sjögren's Syndrome Patients.International journal of molecular sciences · 2022Article
- Transmembrane Mucin 1 Blocks Fluorescein Ingress to Corneal Epithelium.Investigative ophthalmology & visual science · 2022Article
- Human ocular mucins: The endowed guardians of sight.Advanced drug delivery reviews · 2022Review
- Impact of Air Pollution on the Ocular Surface and Tear Cytokine Levels: A Multicenter Prospective Cohort Study.Frontiers in medicine · 2022Article
- Short tear film breakup time-type of dry eye in India.Indian journal of ophthalmology · 2021Article
- Gene expression profiles of pro-inflammatory mediators in the conjunctiva of patients with epiblepharon.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Tear Film Cytokine Profile of Patients With the Boston Keratoprosthesis Type 1: Comparing Patients With and Without Glaucoma.Investigative ophthalmology & visual science · 2021Article
- Toxicological effects of urban particulate matter on corneal and conjunctival epithelial cells.Toxicological research · 2020Article
- Disrupted Glycocalyx as a Source of Ocular Surface Biomarkers.Eye & contact lens · 2020Review
- Apricot Kernel Extract and Amygdalin Inhibit Urban Particulate Matter-Induced Keratoconjunctivitis Sicca.Molecules (Basel, Switzerland) · 2019Article
- Clusterin from human clinical tear samples: Positive correlation between tear concentration and Schirmer strip test results.The ocular surface · 2018Article
- Changes in Distribution of Dry Eye Disease by the New 2016 Diagnostic Criteria from the Asia Dry Eye Society.Scientific reports · 2018Observational
- TFOS DEWS II Tear Film Report.The ocular surface · 2017Review
- Effect of mistletoe combined with carboxymethyl cellulose on dry eye in postmenopausal women.International journal of ophthalmology · 2017Article
- Concentrations of MUC16 and MUC5AC using three tear collection methods.Molecular vision · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo determine if levels of the glycocalyx membrane mucins, MUC1 and MUC16, and the secreted goblet cell mucin MUC5AC are altered in conjunctival cells and tears of postmenopausal women presenting with a history of non-Sjögren dry eye and if mucin levels correlate with dry eye clinical diagnostic data.
methodsEighty-four postmenopausal women with a history of non-Sjögren dry eye and 30 normal subjects were recruited for this study. Impression cytology samples were collected for mucin messenger RNA (mRNA) and protein analysis. Tears were collected for mucin protein assay. Quantitative polymerase chain reaction, Western blot, and enzyme-linked immunosorbent assay were used to quantitate MUC1, MUC16, and MUC5AC levels.
resultsPostmenopausal women with a history of dry eye displayed significantly increased MUC1 mRNA expression and cellular protein compared with normal subjects (P < 0.001 and P < 0.01, respectively). Similarly, cellular MUC16 protein levels were significantly higher (P < 0.001). Mucin levels were found to be correlated with the clinical characterization of the subjects, including staining and symptoms. Although cellular MUC5AC protein levels were increased in symptomatic subjects, the increase did not reach statistical significance.
conclusionsElevation in MUC1 and MUC16 mRNA and/or protein levels in postmenopausal women with non-Sjögren dry eye with a history of dry eye may be a compensatory response to irritation and inflammation associated with the disease. Understanding the pattern of mucin expression associated with the dry eye pathology may clarify factors involved in the progression of the disease and enhance the development of targeted therapies.
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Registered trials
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