ReviewTrends in parasitology2012
Trypanosomes and the solution to a 50-year mitochondrial calcium mystery.
Review in Trends in parasitology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- MICU1 and MICU2 potentiation of CaCell calcium · 2022Article
- Mitochondrial CaAntioxidants & redox signaling · 2022Review
- Trypanosoma cruzi Letm1 is involved in mitochondrial CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Intracellular CaInternational journal of molecular sciences · 2021Review
- Mitochondrial CaInternational review of cell and molecular biology · 2021Review
- Article
- Functional analysis and importance for host cell infection of the CaMolecular biology of the cell · 2019Article
- Article
- Calcium-sensitive pyruvate dehydrogenase phosphatase is required for energy metabolism, growth, differentiation, and infectivity ofThe Journal of biological chemistry · 2018Article
- Calcium signaling and the lytic cycle of the Apicomplexan parasite Toxoplasma gondii.Biochimica et biophysica acta. Molecular cell research · 2018Review
- The Mitochondrial CamBio · 2018Article
- Review
- The mitochondrial calcium uniporter complex in trypanosomes.Cell biology international · 2018Review
- Acidocalcisome-Mitochondrion Membrane Contact Sites in Trypanosoma brucei.Pathogens (Basel, Switzerland) · 2018Article
- A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex.PLoS pathogens · 2017Review
- Different Roles of Mitochondrial Calcium Uniporter Complex Subunits in Growth and Infectivity ofmBio · 2017Article
- CRISPR/Cas9-mediated endogenous C-terminal Tagging of Trypanosoma cruzi Genes Reveals the Acidocalcisome Localization of the Inositol 1,4,5-Trisphosphate Receptor.The Journal of biological chemistry · 2016Article
- The Oral Antimalarial Drug Tafenoquine Shows Activity against Trypanosoma brucei.Antimicrobial agents and chemotherapy · 2015Article
- Calcium signaling in trypanosomatid parasites.Cell calcium · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The ability of mitochondria to take up Ca(2+) was discovered 50 years ago. This calcium uptake, through a mitochondrial calcium uniporter (MCU), is important not only for the regulation of cellular ATP concentration but also for more complex pathways such as shaping Ca(2+) signals and the activation of programmed cell death. The molecular nature of the uniporter remained unknown for decades. By a comparative study of mitochondrial protein profiles of organisms lacking or possessing MCU, such as yeast in the former case and vertebrates and trypanosomes in the latter, two groups recently found the protein that possesses all the characteristics of the MCU. These results add another success story to the already substantial contributions of trypanosomes to mammalian biochemistry.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.