Evidence map›Paper›PMID 22088938›Full record

Trial reportLung cancer (Amsterdam, Netherlands)2012

A pilot test of a combined tobacco dependence treatment and lung cancer screening program.

Amy K Ferketich, Gregory A Otterson, Mark King, Nathan Hall, Kristine K Browning, Mary Ellen Wewers

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Lung cancer (Amsterdam, Netherlands), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04149249 (CONNECT), which is not on this map. Cited by 34 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 9 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04149249 nacompletednot on this mapstarted 2019, after this paper: background citation

CONNECT: Smoking Cessation and Lung Cancer Screening

TypeinterventionalSponsorUniversity of California, San FranciscoRan2019 to 2023Enrolled99ConditionsSmoking CessationArmsComputer-Assisted Intervention Video Doctor, Computer-Assisted Intervention no Video Doctor
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 9 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Nicotine receptor partial agonists for smoking cessation.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Pooled it
  3. Biomedical risk assessment as an aid for smoking cessation.The Cochrane database of systematic reviews · 2019
    Pooled it
  4. Guideline
  5. Nicotine receptor partial agonists for smoking cessation.The Cochrane database of systematic reviews · 2016
    Pooled it
  6. Guideline
  7. Pooled it
  8. Guideline
  9. Pooled it
  10. Trial
  11. Trial
  12. Trial
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Amy K FerketichThe Ohio State University College of Public Health, Columbus, OH 43210, USA. aferketich@cph.osu.edu
Gregory A Otterson
Mark King
Nathan Hall
Kristine K Browning
Mary Ellen Wewers
The Ohio State University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI WANCAI YANG · 1985 to 2026
$132.3M
NCI NIH HHS P30 CA016058
6 · The paper itself

Abstract

Lung cancer screening with computed tomography has demonstrated a significant reduction in mortality. While these findings are important for the lung cancer research field, the most important risk factor for lung cancer, i.e. smoking, should not be ignored. We performed a pilot study to examine the feasibility of delivering a program that included both tobacco dependence treatment and lung cancer screening. The objectives of this study were to: (1) estimate the proportion of smokers who complied with a 12-week treatment protocol that included both tobacco dependence treatment and lung cancer screening, (2) obtain preliminary estimates of abstinence and quit attempts at 4 and 6 months, and (3) obtain preliminary estimates of the cognitive social health information processing (C-SHIP) constructs and how they change following the intervention. In this randomized pilot study, 18 volunteers completed a 12-week protocol: half received the tobacco dependence treatment program before a CT scan (BCT) and the other received the CT scan first, followed by the treatment program (ACT). The treatment protocol included both nurse-delivered telephone counseling and either nicotine replacement therapy or varenicline. Only one person did not complete all follow-up evaluations. At 4 months post enrollment, the carbon monoxide confirmed quit rates were 33.3% in the BCT arm and 22.2% in the ACT arm (27.8% overall), and all but one had made a 24-h attempt to quit. At 6 months the confirmed abstinence decreased to 22.1% in the BCT arm and 11.1% in the ACT arm (16.7% overall), and 72.2% of participants had made a 24-h quit attempt. These preliminary results suggest that it might be better to deliver treatment before the screening test. Future randomized trials with a larger sample size are needed to confirm these findings.

Indexed as

BenzazepinesEarly Detection of CancerFemaleFollow-Up StudiesHumansLung NeoplasmsMaleMiddle AgedPilot ProjectsQuinoxalinesSmokingSmoking CessationTobacco Use Cessation DevicesTobacco Use DisorderTomography, X-Ray ComputedVareniclineBenzazepinesQuinoxalinesVarenicline

Identifiers

PMID22088938
PMCPMC4272196
OpenAlexW2118119028

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.