Evidence map›Paper›PMID 22088795›Full record

Trial reportBiological psychiatry2012

Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics.

Michael H Antoni, Susan K Lutgendorf, Bonnie Blomberg, Charles S Carver, Suzanne Lechner, Alain Diaz, Jamie Stagl, Jesusa M G Arevalo, Steven W Cole

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06583395 (Effects Of Meditation On The Gut Microbiome And Human Health and Disease), which is not on this map. Cited by 141 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed, 4 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06583395 enrolling by invitationnot on this mapstarted 2021, after this paper: background citation

Effects Of Meditation On The Gut Microbiome And Human Health and Disease

TypeobservationalSponsorTobias Moeller-BertramRan2021 to 2025Enrolled3,000ConditionsAmyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, AsthmaArmsAdvanced multi-component meditation practice
3 · Its place in the literature

Who cites it

141 citing papers in PubMed, 4 syntheses or guidelines pooled it, 246 citations in OpenAlex.

  1. Resilience interventions for stress-related health outcomes in patients with cancer: Findings from a systematic review of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Michael H AntoniDepartment of Psychology, University of Miami, Coral Gables, 5665 Ponce DeLeon Boulevard, Coral Gables, FL 33124-0751, USA. MAntoni@miami.edu
Susan K Lutgendorf
Bonnie Blomberg
Charles S Carver
Suzanne Lechner
Alain Diaz
Jamie Stagl
Jesusa M G Arevalo
Steven W Cole
Sylvester Comprehensive Cancer Center · USUniversity of California, Los Angeles · USUniversity of Miami Hospital · USAmerican Orchid Society · USUniversity of Iowa · USUniversity of Miami · US

Funding

Urology Chronic Pelvic Pain Longitudinal Symptom Patterns StudyU01DK082344 · NIDDK · UNIVERSITY OF IOWA · PI KREDER, KARL J · 2008 to 2021
$9.8M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
UCLA OLDER AMERICANS INDEPENDENT CENTERP60AG010415 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUBEN, DAVID B. · 1991 to 2005
$8.0M
FACILITATING POSITIVE ADAPTATION TO BREAST CANCERR01CA064710 · NCI · UNIVERSITY OF MIAMI CORAL GABLES · PI ANTONI, MICHAEL HOWARD · 1994 to 2010
$4.2M
Biobehavioral Influences and the Ovarian Tumor MicroenvironmentR01CA140933 · NCI · UNIVERSITY OF IOWA · PI LUTGENDORF, SUSAN K · 2009 to 2013
$2.8M
Combinatorial Genomics in CancerR01CA116778 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COLE, STEVE W · 2006 to 2010
$1.5M
Autonomic nervous system control of HIV-1 replicationR01AI052737 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COLE, STEVE W · 2002 to 2005
$1.1M
NCI NIH HHS CA064710NCI NIH HHS CA116778NCI NIH HHS CA140933NCI NIH HHS R01 CA064710NCI NIH HHS R01 CA116778NCI NIH HHS R01 CA140933NIAID NIH HHS AI052737NIAID NIH HHS R01 AI052737NIA NIH HHS AG010415NIA NIH HHS AG028748NIA NIH HHS AG107265NIA NIH HHS P30 AG028748NIA NIH HHS P60 AG010415NIDDK NIH HHS DK082344NIDDK NIH HHS U01 DK082344
6 · The paper itself

Abstract

backgroundChronic threat and anxiety are associated with pro-inflammatory transcriptional profiles in circulating leukocytes, but the causal direction of that relationship has not been established. This study tested whether a cognitive-behavioral stress management (CBSM) intervention targeting negative affect and cognition might counteract anxiety-related transcriptional alterations in people confronting a major medical threat.

methodsOne hundred ninety-nine women undergoing primary treatment of stage 0-III breast cancer were randomized to a 10-week CBSM protocol or an active control condition. Seventy-nine provided peripheral blood leukocyte samples for genome-wide transcriptional profiling and bioinformatic analyses at baseline, 6-month, and 12-month follow-ups.

resultsBaseline negative affect was associated with >50% differential expression of 201 leukocyte transcripts, including upregulated expression of pro-inflammatory and metastasis-related genes. CBSM altered leukocyte expression of 91 genes by >50% at follow-up (group × time interaction), including downregulation of pro-inflammatory and metastasis-related genes and upregulation of type I interferon response genes. Promoter-based bioinformatic analyses implicated decreased activity of NF-κB/Rel and GATA family transcription factors and increased activity of interferon response factors and the glucocorticoid receptor as potential mediators of CBSM-induced transcriptional alterations.

conclusionsIn early-stage breast cancer patients, a 10-week CBSM intervention can reverse anxiety-related upregulation of pro-inflammatory gene expression in circulating leukocytes. These findings clarify the molecular signaling pathways by which behavioral interventions can influence physical health and alter peripheral inflammatory processes that may reciprocally affect brain affective and cognitive processes.

Indexed as

Breast NeoplasmsInflammationStress, PsychologicalAnxietyClinical ProtocolsCognitive Behavioral TherapyFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGenome-Wide Association StudyHumansImmunityLeukocytesNeoplasm StagingTranscription, GeneticTreatment Outcome

Identifiers

PMID22088795
PMCPMC3264698
OpenAlexW1969951942

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.