ArticleDrug and alcohol dependence2012
Atypical frontal lobe activity during verbal working memory in youth with a family history of alcoholism.
Article in Drug and alcohol dependence, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Meta-analysis and review of functional neuroimaging differences underlying adolescent vulnerability to substance use.NeuroImage · 2020Pooled it
- Trial
- Increased forebrain activations in youths with family histories of alcohol and other substance use disorders performing a Go/NoGo task.Alcoholism, clinical and experimental research · 2014Trial
- Untangling relationships between cognitive development and child and adolescent mental health: Findings from the ABCD Study.Developmental cognitive neuroscience · 2026Review
- Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder.Nature. Mental health · 2025Article
- The Genetically Informed Neurobiology of Addiction (GINA) model.Nature reviews. Neuroscience · 2023Review
- Adolescent novelty seeking is associated with greater ventral striatal and prefrontal brain response during evaluation of risk and reward.Cognitive, affective & behavioral neuroscience · 2022Article
- Behavioral and brain signatures of substance use vulnerability in childhood.Developmental cognitive neuroscience · 2020Article
- The effect of alcohol use on neuroimaging correlates of cognitive and emotional processing in human adolescence.Neuropsychology · 2019Review
- Increased Neural Activity in Hazardous Drinkers During High Workload in a Visual Working Memory Task: A Preliminary Assessment Through Event-Related Potentials.Frontiers in psychiatry · 2019Article
- Cortical thickness and trait empathy in patients and people at high risk for alcohol use disorders.Psychopharmacology · 2017Article
- Changes in marijuana use symptoms and emotional functioning over 28-days of monitored abstinence in adolescent marijuana users.Psychopharmacology · 2017Article
- Disrupted Control Network Connectivity in Abstinent Patients with Alcohol Dependence.Psychiatry investigation · 2017Article
- Differentiating the Effects of Familial Risk for Alcohol Dependence and Prenatal Exposure to Alcohol on Offspring Brain Morphology.Alcoholism, clinical and experimental research · 2017Article
- The Role of Working Memory for Cognitive Control in Anorexia Nervosa versus Substance Use Disorder.Frontiers in psychology · 2017Review
- Informing the Structure of Executive Function in Children: A Meta-Analysis of Functional Neuroimaging Data.Frontiers in human neuroscience · 2017Article
- Early-Life Adversity Interacts with FKBP5 Genotypes: Altered Working Memory and Cardiac Stress Reactivity in the Oklahoma Family Health Patterns Project.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Lower Working Memory Performance in Overweight and Obese Adolescents Is Mediated by White Matter Microstructure.Journal of the International Neuropsychological Society : JINS · 2016Article
- The impact of therapists' words on the adolescent brain: In the context of addiction treatment.Behavioural brain research · 2016Article
- Neurobiological phenotypes associated with a family history of alcoholism.Drug and alcohol dependence · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAbnormal brain functioning during verbal working memory (VWM) tasks has been shown in individuals with alcohol use disorders (AUDs). Since adolescents with a familial history of alcoholism (FHP) are at high risk for developing an AUD, it is important to consider whether atypical brain activity during VWM may help to explain FHP vulnerability toward developing alcoholism.
methodsTo that end, using functional magnetic resonance imaging, we examined brain response during a VWM 2-back task in 19 FHP adolescents and 16 age and gender-matched family history negative (FHN) controls.
resultsDespite no group differences in task accuracy, FHP youth had significantly slower average reaction time when making correct responses during the 2-back condition than FHN youth. In contrast to a vigilance control condition, while covarying for reaction time, FHP adolescents showed less activation during VWM than FHN youth in multiple areas of the prefrontal cortex (PFC)--a brain region crucial to intact working memory skills.
conclusionsThese results suggest that even prior to heavy alcohol use, FHP adolescents show atypical executive brain functioning during VWM, and that these differences are independent of slower working memory reaction time in FHP youth. Given the importance of working memory in numerous areas of day-to-day functioning, such as adaptive decision-making, these abnormalities may contribute to FHP youth vulnerability toward developing AUDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.