Evidence map›Paper›PMID 22088391›Full record

ReviewCurrent opinion in neurobiology2012

Nanoscale analysis of structural synaptic plasticity.

Jennifer N Bourne, Kristen M Harris

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Absolute Number of Three Populations of Interneurons and All GABAergic Synapses in the Human Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Review
  6. Fiber-basedNeurophotonics · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. The dendritic engram.Frontiers in behavioral neuroscience · 2023
    Article
  11. Structural and functional imaging of brains.Science China. Chemistry · 2023
    Review
  12. Article
  13. Unique transsynaptic complexes enable long-term synaptic plasticity in a synapse-specific manner.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. The MeshCODE to scale-visualising synaptic binary information.Frontiers in cellular neuroscience · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jennifer N BourneCenter for Learning and Memory, Department of Neurobiology, University of Texas, Austin, TX 78712-0805, USA.
Kristen M Harris

Funding

Spine and Synaptic Plasticity in Mature HippocampusR37NS021184 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI HARRIS, KRISTEN M · 2005 to 2011
$2.2M
Distance-Dependent Structure and Function of Neuronal DendritesR01EB002170 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI HARRIS, KRISTEN M · 2003 to 2010
$2.1M
Synapse growth and elimination in mature CNSR01MH104319 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI HARRIS, KRISTEN M · 2014 to 2018
$1.8M
Distance-Dependent Structure and Function of Neuronal DendritesR01NS074644 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI HARRIS, KRISTEN M · 2011 to 2015
$1.7M
NIBIB NIH HHS R01 EB002170NIMH NIH HHS R01 MH104319NINDS NIH HHS R01 NS074644NINDS NIH HHS R37 NS021184
6 · The paper itself

Abstract

Structural plasticity of dendritic spines and synapses is an essential mechanism to sustain long lasting changes in the brain with learning and experience. The use of electron microscopy over the last several decades has advanced our understanding of the magnitude and extent of structural plasticity at a nanoscale resolution. In particular, serial section electron microscopy (ssEM) provides accurate measurements of plasticity-related changes in synaptic size and density and distribution of key cellular resources such as polyribosomes, smooth endoplasmic reticulum, and synaptic vesicles. Careful attention to experimental and analytical approaches ensures correct interpretation of ultrastructural data and has begun to reveal the degree to which synapses undergo structural remodeling in response to physiological plasticity.

Indexed as

AnimalsDendritesDendritic SpinesHumansMicroscopy, ElectronModels, AnatomicNanotechnologyNeuronal PlasticityNeuronsSynapses

Identifiers

PMID22088391
PMCPMC3292623

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.