ArticleThe Journal of the Acoustical Society of America2011
Acoustic characterization of echogenic liposomes: frequency-dependent attenuation and backscatter.
Article in The Journal of the Acoustical Society of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Comparison of Acoustofluidic and Static Systems for Ultrasound-Mediated Molecular Delivery to T Lymphocytes.Ultrasound in medicine & biology · 2023Article
- Experimental acoustic characterization of an endoskeletal antibubble contrast agent: First results.Medical physics · 2021Article
- Bursting Microbubbles: How Nanobubble Contrast Agents Can Enable the Future of Medical Ultrasound Molecular Imaging and Image-Guided Therapy.Current opinion in colloid & interface science · 2021Article
- Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles.Ultrasonics sonochemistry · 2021Article
- Echogenic Exosomes as ultrasound contrast agents.Nanoscale advances · 2020Article
- In vitro characterization of sonothrombolysis and echocontrast agents to treat ischemic stroke.Scientific reports · 2019Article
- A Spectral Fiedler Field-based Contrast Platform for Imaging of Nanoparticles in Colon Tumor.Scientific reports · 2018Article
- Role of freeze-drying in the presence of mannitol on the echogenicity of echogenic liposomes.The Journal of the Acoustical Society of America · 2017Article
- Quantitative Frequency-Domain Passive Cavitation Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2017Article
- Loss of gas from echogenic liposomes exposed to pulsed ultrasound.Physics in medicine and biology · 2016Article
- Microfluidic manufacture of rt-PA -loaded echogenic liposomes.Biomedical microdevices · 2016Article
- Ultrasound-enhanced bevacizumab release from echogenic liposomes for inhibition of atheroma progression.Journal of liposome research · 2016Article
- Cell mechanics in biomedical cavitation.Interface focus · 2015Review
- Nitric Oxide-Enhanced Molecular Imaging of Atheroma using Vascular Cellular Adhesion Molecule 1-Targeted Echogenic Immunoliposomes.Ultrasound in medicine & biology · 2015Article
- Impulse response method for characterization of echogenic liposomes.The Journal of the Acoustical Society of America · 2015Article
- Plasmin-loaded echogenic liposomes for ultrasound-mediated thrombolysis.Translational stroke research · 2015Article
- Integration of acoustic radiation force and optical imaging for blood plasma clot stiffness measurement.PloS one · 2015Article
- Loss of echogenicity and onset of cavitation from echogenic liposomes: pulse repetition frequency independence.Ultrasound in medicine & biology · 2015Article
- Quantitative assessment of cancer vascular architecture by skeletonization of high-resolution 3-D contrast-enhanced ultrasound images: role of liposomes and microbubbles.Technology in cancer research & treatment · 2014Article
- pH-triggered echogenicity and contents release from liposomes.Molecular pharmaceutics · 2014Article
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Authors and funding
10 authors.
Funding
Abstract
Ultrasound contrast agents (UCAs) are used clinically to aid detection and diagnosis of abnormal blood flow or perfusion. Characterization of UCAs can aid in the optimization of ultrasound parameters for enhanced image contrast. In this study echogenic liposomes (ELIPs) were characterized acoustically by measuring the frequency-dependent attenuation and backscatter coefficients at frequencies between 3 and 30 MHz using a broadband pulse-echo technique. The experimental methods were initially validated by comparing the attenuation and backscatter coefficients measured from 50-μm and 100-μm polystyrene microspheres with theoretical values. The size distribution of the ELIPs was measured and found to be polydisperse, ranging in size from 40 nm to 6 μm in diameter, with the highest number observed at 65 nm. The ELIP attenuation coefficients ranged from 3.7 ± 1.0 to 8.0 ± 3.3 dB/cm between 3 and 25 MHz. The backscatter coefficients were 0.011 ± 0.006 (cm str)(-1) between 6 and 9 MHz and 0.023 ± 0.006 (cm str)(-1) between 13 and 30 MHz. The measured scattering-to-attenuation ratio ranged from 8% to 22% between 6 and 25 MHz. Thus ELIPs can provide enhanced contrast over a broad range of frequencies and the scattering properties are suitable for various ultrasound imaging applications including diagnostic and intravascular ultrasound.
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