ArticleClinical and experimental immunology1990
Plasma and tissue interleukin-2 receptor levels in inflammatory bowel disease.
Article in Clinical and experimental immunology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- A systematic review of the effect of structured exercise on inflammation and body composition in inflammatory bowel disease.International journal of colorectal disease · 2023Pooled it
- Differences in immunophenotyping of mucosal lymphocytes between ulcerative colitis and Crohn's disease.The Korean journal of internal medicine · 1997Trial
- Suppression of NK Cell Activation by JAK3 Inhibition: Implication in the Treatment of Autoimmune Diseases.Journal of immunology research · 2023Article
- Role of serotonin on the intestinal mucosal immune response to stress-induced diarrhea in weaning mice.BMC gastroenterology · 2017Article
- Blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in patients with symptoms suggesting reactive hypoglycemia.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Article
- Molecular mechanism of interleukin-2-induced mucosal homeostasis.American journal of physiology. Cell physiology · 2012Article
- Cytokine soluble receptors in perinatal and early neonatal life.Mediators of inflammation · 2003Article
- Inflammatory bowel disease: definition, epidemiology, etiologic aspects, and immunogenetic studies.World journal of gastroenterology · 1998Article
- In vitro production of TNF-alpha,IL-6 and sIL-2R in Chinese patients with ulcerative colitis.World journal of gastroenterology · 1998Article
- Common variable immunodeficiency with CD4+ T lymphocytopenia and overproduction of soluble IL-2 receptor associated with Turner's syndrome and dorsal kyphoscoliosis.Journal of clinical pathology · 1997Article
- Immunopathology of human inflammatory bowel disease.Springer seminars in immunopathology · 1997Review
- Increased mucosal concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), sE-selectin, and interleukin-8 in active ulcerative colitis.Digestive diseases and sciences · 1996Article
- Soluble interleukin-2 receptor in Crohn's disease. Assessment of disease activity and prediction of relapse.Digestive diseases and sciences · 1995Article
- Adequacy of mucosal biopsies for evaluation of intestinal cytokine-specific mRNA. Comparative study of RT-PCR in biopsies and isolated cells from normal and inflamed intestine.Digestive diseases and sciences · 1995Article
- Circulating antiinflammatory cytokine IL-10 in patients with inflammatory bowel disease (IBD).Clinical and experimental immunology · 1995Article
- Review
- Crohn's disease and multiple sclerosis: a single case report.Italian journal of neurological sciences · 1994Article
- Review
- Soluble interleukin-2 receptors in ulcerative colitis.Mediators of inflammation · 1993Article
- IL-2 production by intestinal lamina propria cells in normal inflamed and cancer-bearing colons.Clinical and experimental immunology · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasma and tissue interleukin-2 receptor (IL-2R) levels were determined in patients with active ulcerative colitis and Crohn's disease. Compared with healthy controls (median 440 U/ml; range 240-900), significantly higher levels of plasma IL-2R were present in patients with active ulcerative colitis (median 1180 U/ml; range 580-7150; P less than 0.002) and Crohn's disease (median 1340 U/ml; range 480-9000; P less than 0.002). Compared with other laboratory parameters, plasma IL-2R levels were related most closely to clinical score of disease activity in Crohn's disease. Plasma IL-2R levels also reflected the clinical course and may provide a more accurate assessment of disease activity in Crohn's disease. In plasma of patients undergoing intestinal resection of active inflammatory bowel disease, raised levels of IL-2R were present in samples from mesenteric vein (draining inflamed intestine) compared with those from peripheral vein. In tissue homogenates of colonic biopsies, significantly higher levels of IL-2R were present in specimens from colons with active ulcerative colitis compared with healthy controls (median 230.2, range 20.7-581.5 versus 77.9, range 34.2-291.3; P less than 0.02).
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