Evidence map›Paper›PMID 22087695›Full record

ArticleThe New England journal of medicine2011

Chimeric antigen receptor-modified T cells in CLL.

James N Kochenderfer, Steven A Rosenberg

Registry-linked trialAbstract readLetterComment
In one paragraph

Article in The New England journal of medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03240328 (The Effect of CAR-T Cell Therapy on the Reconstitution of HIV-specific Immune Function), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03240328 phase1recruitingnot on this mapstarted 2017, after this paper: background citation

The Effect of CAR-T Cell Therapy on the Reconstitution of HIV-specific Immune Function

TypeinterventionalSponsorGuangzhou 8th People's HospitalRan2017 to 2030Enrolled40ConditionsHIV/AIDSArmsCAR-T cells
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. CD81 costimulation skews CAR transduction toward naive T cells.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
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  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

James N Kochenderfer
Steven A Rosenberg

Funding

Adoptive Cell Transfer Immunotherapy of CancerZIABC010984 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ROSENBERG, STEVEN · 2009 to 2025
$56.8M
Gene therapy of cancerZIABC010985 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ROSENBERG, STEVEN · 2009 to 2025
$56.8M
Adoptive Cell Transfer Immunotherapy of CancerZ01BC010984 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ROSENBERG, STEVEN · 2008 to 2008
$1.5M
Intramural NIH HHS Z01 BC010984
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antigens, CD19ImmunotherapyReceptors, Antigen, T-CellHumansLeukemia, LymphoidMaleT-LymphocytesAntigens, CD19Receptors, Antigen, T-Cell

Identifiers

PMID22087695
PMCPMC6348466

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.