ArticlePloS one2011
Stable small animal ventilation for dynamic lung imaging to support computational fluid dynamics models.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Ventilation-perfusion effects of negative-pressure ventilation: insights from an experimental rat model.Intensive care medicine experimental · 2026Article
- Comparison of CT-derived ventilation maps with deposition patterns of inhaled microspheres in rats.Experimental lung research · 2015Article
- Automated measurement of heterogeneity in CT images of healthy and diseased rat lungs using variogram analysis of an octree decomposition.BMC medical imaging · 2014Article
- Detecting radiation-induced injury using rapid 3D variogram analysis of CT images of rat lungs.Academic radiology · 2013Article
- In situ casting and imaging of the rat airway tree for accurate 3D reconstruction.Experimental lung research · 2013Article
- Article
- An efficient algorithm for mapping imaging data to 3D unstructured grids in computational biomechanics.International journal for numerical methods in biomedical engineering · 2013Article
- Imaging for lung physiology: what do we wish we could measure?Journal of applied physiology (Bethesda, Md. : 1985) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Pulmonary computational fluid dynamics models require that three-dimensional images be acquired over multiple points in the dynamic breathing cycle without breath holds or changes in ventilatory mechanics. With small animals, these requirements can result in long imaging times (∼90 minutes), over which lung mechanics, such as compliance, may gradually change if not carefully monitored and controlled. These changes, caused by derecruitment of parenchymal tissue, are manifested as an upward drift in peak inspiratory pressure (PIP) or by changes in the pressure waveform and/or lung volume over the course of the experiment. We demonstrate highly repeatable mechanical ventilation in anesthetized rats over a long duration for dynamic lung x-ray computed tomography (CT) imaging. We describe significant updates to a basic commercial ventilator that was acquired for these experiments. Key to achieving consistent results was the implementation of periodic deep breaths, or sighs, of extended duration to maintain lung recruitment. In addition, continuous monitoring of breath-to-breath pressure and volume waveforms and long-term trends in PIP and flow provide diagnostics of changes in breathing mechanics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.