ArticlePloS one2011
Lymphangiogenesis in regional lymph nodes is an independent prognostic marker in rectal cancer patients after neoadjuvant treatment.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Rectal Cancer: Are 12 Lymph Nodes the Limit?Cancers · 2023Article
- Article
- Widespread anorectal lymphovascular networks and tissue drainage: analyses from submucosal India ink injection and indocyanine green fluorescence imaging.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2021Article
- Tumor Regulation of Lymph Node Lymphatic Sinus Growth and Lymph Flow in Mice and in Humans.The Yale journal of biology and medicine · 2017Review
- Distinct mechanisms of B and T lymphocyte accumulation generate tumor-draining lymph node hypertrophy.Oncoimmunology · 2016Article
- [The metastatic niche. Mechanisms and prognostic implications].Der Pathologe · 2015Review
- Tumor-induced lymph node alterations detected by MRI lymphography using gadolinium nanoparticles.Scientific reports · 2015Article
- Tumor-induced alterations in lymph node lymph drainage identified by contrast-enhanced MRI.Journal of magnetic resonance imaging : JMRI · 2015Article
- Vascular remodeling in cancer.Oncogene · 2014Review
- The prognostic significance of peroxisome proliferator-activated receptor β expression in the vascular endothelial cells of colorectal cancer.Journal of gastroenterology · 2014Article
- Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model.Clinical & experimental metastasis · 2014Article
- Article
- Article
- Article
- The metastatic niche and stromal progression.Cancer metastasis reviews · 2012Review
- The connectivity of lymphogenous and hematogenous tumor cell dissemination: biological insights and clinical implications.Clinical & experimental metastasis · 2012Review
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6 authors.
Funding
Abstract
One of the major prognostic factors in rectal cancer is lymph node metastasis. The formation of lymph node metastases is dependent on the existence of a premetastatic niche. An important factor preceding metastasis are lymph vessels which are located in the lymph node. Accordingly, the occurrence of intranodal lymphangiogenesis is thought to indicate distant metastasis and worse prognosis. To evaluate the significance of lymph node lymphangiogenesis, we studied formalin fixed, paraffin embedded adenocarcinomas and regional lymph nodes of 203 rectal cancer patients who were treated with neoadjuvant radiochemotherapy and consecutive curative surgery with cancer free surgical margins (R0). Regional lymph node lymph vessels were detected by immunohistochemistry for podoplanin (D2-40). Our results show that the presence of lymphatic vessels in regional lymph nodes significantly affects the disease-free survival in univariate and multivariate analyses. In contrast, there was no correlation between peritumoral or intratumoral lymph vessel density and prognosis. Indeed, our study demonstrates the importance of lymphangiogenesis in regional lymph nodes after neoadjuvant radiochemotherapy and consecutive surgery as an independent prognostic marker. Staining for intranodal lymphangiogenesis and methods of intravital imaging of lymphangiogenesis and lymphatic flow may be a useful strategy to predict long-term outcome in rectal cancer patients. Furthermore, addition of VEGF-blocking agents to standardized neoadjuvant treatment schemes might be indicated in advanced rectal cancer.
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