ArticlePloS one2011
Human cumulus cells molecular signature in relation to oocyte nuclear maturity stage.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cumulus cell antioxidant system is modulated by patients' clinical characteristics and correlates with embryo development.Journal of assisted reproduction and genetics · 2022Pooled it
- Trial
- The Role of Cumulus Cells for The Immature Oocyte Undergoing In Vitro Maturation Rescue: A Retrospective Analysis.International journal of fertility & sterility · 2025Article
- Maturational competence of equine oocytes is associated with alterations in their 'cumulome'.Molecular human reproduction · 2024Article
- Long pentraxin 3 and vitamin D receptor mRNA expression pattern of cumulus granulosa cells isolated from PCOS oocytes at different stages of nuclear maturation.Reproductive biology and endocrinology : RB&E · 2024Article
- Transcriptome Signature of Immature and In Vitro-Matured Equine Cumulus-Oocytes Complex.International journal of molecular sciences · 2023Article
- TGFß Gene Members and Their Regulatory Factors in Granulosa Compared to Cumulus Cells in PCOS: A Case-Control Study.Cell journal · 2022Article
- Transcriptomic analysis of cumulus cells shows altered pathways in patients with minimal and mild endometriosis.Scientific reports · 2022Article
- Dysregulated sphingolipid metabolism and autophagy in granulosa cells of women with endometriosis.Frontiers in endocrinology · 2022Article
- Multi-Omics Analysis and Machine Learning Prediction Model for Pregnancy Outcomes After Intracytoplasmic Sperm Injection-Frontiers in public health · 2022Article
- Stratifying Cumulus Cell Samples Based on Molecular Profiling to Help Resolve Biomarker Discrepancies and to Predict Oocyte Developmental Competence.International journal of molecular sciences · 2021Article
- Transcriptomics of cumulus cells - a window into oocyte maturation in humans.Journal of ovarian research · 2020Article
- Analysis of the equine "cumulome" reveals major metabolic aberrations after maturation in vitro.BMC genomics · 2019Article
- The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner.Oxidative medicine and cellular longevity · 2018Review
- Article
- Single-cell analysis of differences in transcriptomic profiles of oocytes and cumulus cells at GV, MI, MII stages from PCOS patients.Scientific reports · 2016Article
- Bu Shen Tiao Chong recipe restores diminished ovary reserve through the BDNF pathway.Journal of assisted reproduction and genetics · 2016Article
- Altered microRNAs expression profiling in cumulus cells from patients with polycystic ovary syndrome.Journal of translational medicine · 2015Article
- The transcriptome of corona radiata cells from individual MІІ oocytes that after ICSI developed to embryos selected for transfer: PCOS women compared to healthy women.Journal of ovarian research · 2014Article
- A review of luteinising hormone and human chorionic gonadotropin when used in assisted reproductive technology.Reproductive biology and endocrinology : RB&E · 2014Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bi-directional communication between the oocyte and the surrounding cumulus cells (CCs) is crucial for the acquisition of oocyte competence. We investigated the transcriptomic profile of human CCs isolated from mature and immature oocytes under stimulated cycle. We used human Genome U133 Plus 2.0 microarrays to perform an extensive analysis of the genes expressed in human CCs obtained from patients undergoing intra-cytoplasmic sperm injection. CC samples were isolated from oocyte at germinal vesicle, stage metaphase I and stage metaphase II. For microarray analysis, we used eight chips for each CC category. Significance analysis of microarray multiclass was used to analyze the microarray data. Validation was performed by RT-qPCR using an independent cohort of CC samples. We identified differentially over-expressed genes between the three CC categories. This study revealed a specific signature of gene expression in CCs issued from MII oocyte compared with germinal vesicle and metaphase I. The CC gene expression profile, which is specific of MII mature oocyte, can be useful as predictors of oocyte quality.
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Registered trials
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