ArticlePloS one2011
Time-resolved transcriptomics and bioinformatic analyses reveal intrinsic stress responses during batch culture of Bacillus subtilis.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Exploring the lipoproteome of Parageobacillus thermoglucosidasius.Access microbiology · 2026Article
- Exploring and Engineering Novel Strong Promoters for High-Level Protein Expression inMicroorganisms · 2023Article
- The Regulatory Functions of the Multiple Alternative Sigma Factors RpoE, RpoHI, and RpoHII Depend on the Growth Phase inMicroorganisms · 2023Article
- Time-Course Transcriptome Analysis ofMicroorganisms · 2023Article
- The Gene Expression Profile Differs in Growth Phases of theMicroorganisms · 2022Article
- High-Resolution Chrono-Transcriptome of Lactococcus lactis Reveals That It Expresses Proteins with Adapted Size and pI upon Acidification and Nutrient Starvation.Applied and environmental microbiology · 2022Article
- The Quorum Sensing Auto-Inducer 2 (AI-2) Stimulates Nitrogen Fixation and Favors Ethanol Production over Biomass Accumulation inInternational journal of molecular sciences · 2021Article
- Realization of Robust and Precise Regulation of Gene Expression by Multiple Sigma Recognizable Artificial Promoters.Frontiers in bioengineering and biotechnology · 2020Article
- Development of a novel strategy for robust synthetic bacterial promoters based on a stepwise evolution targeting the spacer region of the core promoter in Bacillus subtilis.Microbial cell factories · 2019Article
- Comparative analyses of the variation of the transcriptome and proteome of Rhodobacter sphaeroides throughout growth.BMC genomics · 2019Article
- Metabolic Reprogramming ofFrontiers in microbiology · 2018Article
- Transcriptome profiling analysis reveals metabolic changes across various growth phases in Bacillus pumilus BA06.BMC microbiology · 2017Article
- Resilience in the Face of Uncertainty: Sigma Factor B Fine-Tunes Gene Expression To Support Homeostasis in Gram-Positive Bacteria.Applied and environmental microbiology · 2016Review
- Identification of a highly efficient stationary phase promoter in Bacillus subtilis.Scientific reports · 2015Article
- A fluorescence-based bioassay for antibacterials and its application in screening natural product extracts.The Journal of antibiotics · 2015Article
- Physiological and Transcriptional Responses of Different Industrial Microbes at Near-Zero Specific Growth Rates.Applied and environmental microbiology · 2015Review
- Role of Bacillus subtilis DNA Glycosylase MutM in Counteracting Oxidatively Induced DNA Damage and in Stationary-Phase-Associated Mutagenesis.Journal of bacteriology · 2015Article
- The multidrug ABC transporter BmrC/BmrD of Bacillus subtilis is regulated via a ribosome-mediated transcriptional attenuation mechanism.Nucleic acids research · 2014Article
- Time-related transcriptome analysis of B. subtilis 168 during growth with glucose.Current microbiology · 2014Article
- Ectopic integration vectors for generating fluorescent promoter fusions in Bacillus subtilis with minimal dark noise.PloS one · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have determined the time-resolved transcriptome of the model gram-positive organism B. subtilis during growth in a batch fermentor on rich medium. DNA microarrays were used to monitor gene transcription using 10-minute intervals at 40 consecutive time points. From the growth curve and analysis of all gene expression levels, we identified 4 distinct growth phases and one clear transition point: a lag phase, an exponential growth phase, the transition point and the very clearly separated early and late stationary growth phases. The gene expression profiles suggest the occurrence of stress responses at specific times although no external stresses were applied. The first one is a small induction of the SigB regulon that occurs at the transition point. Remarkably, a very strong response is observed for the SigW regulon, which is highly upregulated at the onset of the late stationary phase. Bioinformatic analyses that were performed on our data set suggest several novel putative motifs for regulator binding. In addition, the expression profiles of several genes appeared to correlate with the oxygen concentration. This data set of the expression profiles of all B. subtilis genes during the entire growth curve on rich medium constitutes a rich repository that can be further mined by the scientific community.
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