ArticleKorean journal of pediatrics2011
Complications of nephrotic syndrome.
Article in Korean journal of pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 61 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Childhood nephrotic syndrome and the clinical profile of thromboembolism: a systematic review and meta-analysis.Pediatric research · 2023Pooled it
- Clinical practice guideline for pediatric idiopathic nephrotic syndrome 2013: general therapy.Clinical and experimental nephrology · 2015Guideline
- Efficacy of higher-dose levamisole in maintaining remission in steroid-dependant nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2017Trial
- A new frontier in edema management: the potential of tolvaptan for refractory edema with hyponatremia in pediatric nephrotic syndrome.Clinical and experimental nephrology · 2026Article
- B4GALT1-related congenital disorder of glycosylation mimicking Ehlers-Danlos syndrome: a child with multisystem involvement and nephrotic syndrome.Clinical and experimental pediatrics · 2026Article
- Article
- Nephrotic syndrome in children: A review.Medicine · 2026Review
- Relapse of Steroid-Dependent Nephrotic Syndrome Despite Long-Term Ciclosporin Therapy in an 11-Year-Old Child: A Case Report and Review on the Management of Nephrotic Syndrome in Children.Case reports in nephrology · 2026Article
- Left ventricular myocardial functions in pediatric patients with primary nephrotic syndrome: a comprehensive evaluation using conventional echocardiography, two-dimensional speckle tracking, and three-dimensional echocardiography.Italian journal of pediatrics · 2025Observational
- Article
- Secondary congenital nephrotic syndrome complicated by acute mesenteric ischemia: A case report.Clinical nephrology. Case studies · 2025Article
- Utility of Clinical, Laboratory, and Radiological Parameters for Detecting Hypovolemia in Edematous Children With Steroid-Sensitive Nephrotic Syndrome-A Prospective Observational Study.International journal of pediatrics · 2025Article
- Nutritional management of pediatric nephrotic syndrome regarding oxidative stress and antioxidant balance.Frontiers in immunology · 2025Review
- Alterations of gut microbiota and metabolome are associated with primary nephrotic syndrome in children.BMC microbiology · 2024Article
- Nephrotic Syndrome Complicated by Pulmonary Embolism and Inferior Vena Cava Thrombosis: A Case Report.Cureus · 2024Article
- Predictors of quality of life (QOL) and treatment adherence among children with nephrotic syndrome.Journal of family medicine and primary care · 2024Article
- Article
- Clostridium butyricum inhibits the inflammation in children with primary nephrotic syndrome by regulating Th17/Tregs balance via gut-kidney axis.BMC microbiology · 2024Article
- Complications Related to Childhood Idiopathic Nephrotic Syndrome, Its Treatment and the Associated Risks in Patients.Cureus · 2023Article
- Relapse of nephrotic syndrome with unusual thromboembolic event: A case report.Clinical case reports · 2023Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nephrotic syndrome (NS) is one of the most common glomerular diseases that affect children. Renal histology reveals the presence of minimal change nephrotic syndrome (MCNS) in more than 80% of these patients. Most patients with MCNS have favorable outcomes without complications. However, a few of these children have lesions of focal segmental glomerulosclerosis, suffer from severe and prolonged proteinuria, and are at high risk for complications. Complications of NS are divided into two categories: disease-associated and drug-related complications. Disease-associated complications include infections (e.g., peritonitis, sepsis, cellulitis, and chicken pox), thromboembolism (e.g., venous thromboembolism and pulmonary embolism), hypovolemic crisis (e.g., abdominal pain, tachycardia, and hypotension), cardiovascular problems (e.g., hyperlipidemia), acute renal failure, anemia, and others (e.g., hypothyroidism, hypocalcemia, bone disease, and intussusception). The main pathomechanism of disease-associated complications originates from the large loss of plasma proteins in the urine of nephrotic children. The majority of children with MCNS who respond to treatment with corticosteroids or cytotoxic agents have smaller and milder complications than those with steroid-resistant NS. Corticosteroids, alkylating agents, cyclosporin A, and mycophenolate mofetil have often been used to treat NS, and these drugs have treatment-related complications. Early detection and appropriate treatment of these complications will improve outcomes for patients with NS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.