ArticlePLoS biology2011
Sperm-storage defects and live birth in Drosophila females lacking spermathecal secretory cells.
Article in PLoS biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed, 138 citations in OpenAlex.
- A novel female reproductive organ differentiates insemination and postmating responses in bedbugs.Molecular biology and evolution · 2026Article
- Transcriptional response of spermathecal secretory cells to mating and receipt of seminal fluid proteins iniScience · 2026Article
- Article
- Ejaculate Ejection by Female Fruit Flies Does Not Correlate With Mating Latency or Male Presence, Irrespective of How Ejection Is Measured.Ecology and evolution · 2025Article
- Female membrane proteins regulate postmating ovulation inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Asymmetric development and function of paired sperm-storage organs inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- A novel male accessory gland peptide reduces female post-mating receptivity in the brown planthopper.PLoS genetics · 2025Article
- Regional specialization, polyploidy, and seminal fluid transcripts in theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Drosophila melanogaster sperm turn more oxidative in the female.The Journal of experimental biology · 2024Article
- Expression and potential regulatory functions of Drosophila octopamine receptors in the female reproductive tract.G3 (Bethesda, Md.) · 2024Article
- Three-dimensional correlative microscopy of the Drosophila female reproductive tract reveals modes of communication in seminal receptacle sperm storage.Communications biology · 2024Article
- The Drosophila melanogaster Y-linked gene, WDY, is required for sperm to swim in the female reproductive tract.Communications biology · 2024Article
- Finishing the egg.Genetics · 2024Article
- Molecular characterization, localization, and physiological roles of ITP and ITP-L in the mosquito,Frontiers in insect science · 2024Article
- Male-derived transcripts isolated from the mated female reproductive tract in Drosophila melanogaster.G3 (Bethesda, Md.) · 2023Article
- Viruses in LaboratoryViruses · 2023Article
- wMel Wolbachia alters female post-mating behaviors and physiology in the dengue vector mosquito Aedes aegypti.Communications biology · 2023Article
- Identifying candidate de novo genes expressed in the somatic female reproductive tract of Drosophila melanogaster.G3 (Bethesda, Md.) · 2023Article
- Evolutionary Quantitative Proteomics of Reproductive Protein Divergence in Drosophila.Molecular & cellular proteomics : MCP · 2023Article
- Transcriptional programs are activated and microRNAs are repressed within minutes after mating in the Drosophila melanogaster female reproductive tract.BMC genomics · 2023Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Male Drosophila flies secrete seminal-fluid proteins that mediate proper sperm storage and fertilization, and that induce changes in female behavior. Females also produce reproductive-tract secretions, yet their contributions to postmating physiology are poorly understood. Large secretory cells line the female's spermathecae, a pair of sperm-storage organs. We identified the regulatory regions controlling transcription of two genes exclusively expressed in these spermathecal secretory cells (SSC): Spermathecal endopeptidase 1 (Send1), which is expressed in both unmated and mated females, and Spermathecal endopeptidase 2 (Send2), which is induced by mating. We used these regulatory sequences to perform precise genetic ablations of the SSC at distinct time points relative to mating. We show that the SSC are required for recruiting sperm to the spermathecae, but not for retaining sperm there. The SSC also act at a distance in the reproductive tract, in that their ablation: (1) reduces sperm motility in the female's other sperm-storage organ, the seminal receptacle; and (2) causes ovoviviparity--the retention and internal development of fertilized eggs. These results establish the reproductive functions of the SSC, shed light on the evolution of live birth, and open new avenues for studying and manipulating female fertility in insects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.