ArticleProceedings of the National Academy of Sciences of the United States of America2012
Brassinosteroids modulate the efficiency of plant immune responses to microbe-associated molecular patterns.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
130 citing papers in PubMed, 1 synthesis or guideline pooled it, 306 citations in OpenAlex.
- Bacillus drives functional states in synthetic plant root bacterial communities.Genome biology · 2025Pooled it
- Dual Roles of Bacillus velezensis ES-120 in Plant Disease Suppression and Growth Promotion.Plant, cell & environment · 2026Article
- Hidden conversations beneath the soil: microRNA and hormone control of root symbioses.Archives of microbiology · 2026Review
- Chemical treatment rescues reduced growth of the autoimmune mutant chs3-2D without compromising its immune responses.Plant biology (Stuttgart, Germany) · 2026Article
- A STRUBBELIG-NHL3 cell surface receptor complex mediates the response to cellulose deficiency in Arabidopsis.Nature plants · 2026Article
- Overexpression of the Receptor-Like Kinase BIR1 Causes SOBIR1- and EDS1-Dependent Cell Death Phenotypes in Arabidopsis.Plant, cell & environment · 2025Article
- Brassinosteroid biosynthesis and signaling: Conserved and diversified functions of core genes across multiple plant species.Plant communications · 2024Review
- Molecular Lesions in BRI1 and Its Orthologs in the Plant Kingdom.International journal of molecular sciences · 2024Review
- Heat Pre-Treatment Modified Host and Non-Host Interactions of Powdery Mildew with Barley Brassinosteroid Mutants and Wild Types.Life (Basel, Switzerland) · 2024Article
- BAK-up: the receptor kinase BAK-TO-LIFE 2 enhances immunity when BAK1 is lacking.Stress biology · 2023Article
- Integrated Transcriptomic and Metabolomic Analyses Uncover the Differential Mechanism in Saline-Alkaline Tolerance betweenInternational journal of molecular sciences · 2023Article
- Spermine inhibits PAMP-induced ROS and Ca2+ burst and reshapes the transcriptional landscape of PAMP-triggered immunity in Arabidopsis.Journal of experimental botany · 2023Article
- Development specifies, diversifies and empowers root immunity.EMBO reports · 2022Review
- The endocytic TPLATE complex internalizes ubiquitinated plasma membrane cargo.Nature plants · 2022Article
- Class I TCP transcription factor AtTCP8 modulates key brassinosteroid-responsive genes.Plant physiology · 2022Article
- Induction of Diverse Cryptic Fungal Metabolites by Steroids and Channel Blockers.Angewandte Chemie (International ed. in English) · 2022Article
- Deubiquitinating enzymes UBP12 and UBP13 stabilize the brassinosteroid receptor BRI1.EMBO reports · 2022Article
- Brassinosteroids Positively Regulate Plant ImmunityFrontiers in plant science · 2022Article
- Tryptophan metabolism and bacterial commensals prevent fungal dysbiosis inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Characterization of evolutionarily distinct rice BAHD-Acyltransferases provides insight into their plausible role in rice susceptibility to Rhizoctonia solani.The plant genome · 2021Article
70 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Metazoans and plants use pattern recognition receptors (PRRs) to sense conserved microbial-associated molecular patterns (MAMPs) in the extracellular environment. In plants, the bacterial MAMPs flagellin and elongation factor Tu (EF-Tu) activate distinct, phylogenetically related cell surface pattern recognition receptors of the leucine-rich repeat receptor kinase (LRR-RK) family called FLS2 and EF-Tu receptor, respectively. BAK1 is an LRR-RK coreceptor for both FLS2 and EF-Tu receptor. BAK1 is also a coreceptor for the plant brassinosteroid (BR) receptor, the LRR-RK BRI1. Binding of BR to BRI1 primarily promotes cell elongation. Here, we tune the BR pathway response to establish how plant cells can generate functionally different cellular outputs in response to MAMPs and pathogens. We demonstrate that BR can act antagonistically or synergistically with responses to MAMPs. We further show that the synergistic activities of BRs on MAMP responses require BAK1. Our results highlight the importance of plant steroid homeostasis as a critical step in the establishment of plant immunity. We propose that tradeoffs associated with plasticity in the face of infection are layered atop plant steroid developmental programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.