ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2011
Mycoplasma hyopneumoniae transcription unit organization: genome survey and prediction.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- The influence of regulatory elements on Mycoplasma hyopneumoniae 7448 transcriptional response during oxidative stress and heat shock.Molecular biology reports · 2022Article
- Global analysis of sRNA target genes in Mycoplasma hyopneumoniae.BMC genomics · 2018Article
- Mycoplasma non-coding RNA: identification of small RNAs and targets.BMC genomics · 2016Article
- Article
- Analysis of strand-specific RNA-seq data using machine learning reveals the structures of transcription units in Clostridium thermocellum.Nucleic acids research · 2015Article
- Intrinsic terminators in Mycoplasma hyopneumoniae transcription.BMC genomics · 2015Article
- Genome organization in Mycoplasma hyopneumoniae: identification of promoter-like sequences.Molecular biology reports · 2014Article
- Article
- New insights on the biology of swine respiratory tract mycoplasmas from a comparative genome analysis.BMC genomics · 2013Article
- Unveiling Mycoplasma hyopneumoniae promoters: sequence definition and genomic distribution.DNA research : an international journal for rapid publication of reports on genes and genomes · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycoplasma hyopneumoniae is associated with swine respiratory diseases. Although gene organization and regulation are well known in many prokaryotic organisms, knowledge on mycoplasma is limited. This study performed a comparative analysis of three strains of M. hyopneumoniae (7448, J and 232), with a focus on genome organization and gene comparison for open read frame (ORF) cluster (OC) identification. An in silico analysis of gene organization demonstrated 117 OCs and 34 single ORFs in M. hyopneumoniae 7448 and J, while 116 OCs and 36 single ORFs were identified in M. hyopneumoniae 232. Genomic comparison revealed high synteny and conservation of gene order between the OCs defined for 7448 and J strains as well as for 7448 and 232 strains. Twenty-one OCs were chosen and experimentally confirmed by reverse transcription-PCR from M. hyopneumoniae 7448 genome, validating our prediction. A subset of the ORFs within an OC could be independently transcribed due to the presence of internal promoters. Our results suggest that transcription occurs in 'run-on' from an upstream promoter in M. hyopneumoniae, thus forming large ORF clusters (from 2 to 29 ORFs in the same orientation) and indicating a complex transcriptional organization.
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Registered trials
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