ArticleNucleic acids research2012
Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Conventional and Alternative B Lymphopoiesis: Multiple Roads to Immunity.Stem cell reviews and reports · 2026Review
- Histiocytic sarcoma with a common clonal origin emerged after 33 years from B-cell precursor acute lymphoblastic leukemia.Journal of clinical and experimental hematopathology : JCEH · 2026Article
- Cellular reprogramming is driven by widespread rewiring of promoter-enhancer interactions.BMC biology · 2023Article
- Stromal-associated cytokines bias the interplay between gene expression and DNA methylation in human breast cancers.Epigenetics · 2020Article
- Unveiling the Role of DNA Methylation in Kidney Transplantation: Novel Perspectives toward Biomarker Identification.BioMed research international · 2019Review
- DNA methylation signal has a major role in the response of human breast cancer cells to the microenvironment.Oncogenesis · 2017Article
- C/EBP-Induced Transdifferentiation Reveals Granulocyte-Macrophage Precursor-like Plasticity of B Cells.Stem cell reports · 2017Article
- Loss of tumorigenic potential upon transdifferentiation from keratinocytic into melanocytic lineage.Scientific reports · 2016Article
- Dedifferentiated fat cells: A cell source for regenerative medicine.World journal of stem cells · 2015Review
- Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors.Nature biotechnology · 2015Article
- Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Cell divisions are not essential for the direct conversion of fibroblasts into neuronal cells.Cell cycle (Georgetown, Tex.) · 2015Article
- Epigenetic control of myeloid cell differentiation, identity and function.Nature reviews. Immunology · 2015Review
- Regulators of pluripotency and their implications in regenerative medicine.Stem cells and cloning : advances and applications · 2015Review
- Article
- The chromatin landscape and transcription factors in T cell programming.Trends in immunology · 2014Review
- C/EBPa-mediated activation of microRNAs 34a and 223 inhibits Lef1 expression to achieve efficient reprogramming into macrophages.Molecular and cellular biology · 2014Article
- Article
- German-Catalan workshop on epigenetics and cancer.Epigenetics · 2013Article
- Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia.EMBO molecular medicine · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription factor-induced lineage reprogramming or transdifferentiation experiments are essential for understanding the plasticity of differentiated cells. These experiments helped to define the specific role of transcription factors in conferring cell identity and played a key role in the development of the regenerative medicine field. We here investigated the acquisition of DNA methylation changes during C/EBPα-induced pre-B cell to macrophage transdifferentiation. Unexpectedly, cell lineage conversion occurred without significant changes in DNA methylation not only in key B cell- and macrophage-specific genes but also throughout the entire set of genes differentially methylated between the two parental cell types. In contrast, active and repressive histone modification marks changed according to the expression levels of these genes. We also demonstrated that C/EBPα and RNA Pol II are associated with the methylated promoters of macrophage-specific genes in reprogrammed macrophages without inducing methylation changes. Our findings not only provide insights about the extent and hierarchy of epigenetic events in pre-B cell to macrophage transdifferentiation but also show an important difference to reprogramming towards pluripotency where promoter DNA demethylation plays a pivotal role.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.