ArticleMolecular cancer research : MCR2012
Association of the von Hippel-Lindau protein with AUF1 and posttranscriptional regulation of VEGFA mRNA.
Article in Molecular cancer research : MCR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Ascites exosomal lncRNA PLADE enhances platinum sensitivity by inducing R-loops in ovarian cancer.Oncogene · 2024Article
- Targeting RNA-binding protein HuR to inhibit the progression of renal tubular fibrosis.Journal of translational medicine · 2023Article
- Review
- RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability.Cell death & disease · 2020Article
- Multiple functions of HuR in urinary tumors.Journal of cancer research and clinical oncology · 2019Review
- Review
- PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity.Nature communications · 2014Article
- Caffeine mediates sustained inactivation of breast cancer-associated myofibroblasts via up-regulation of tumor suppressor genes.PloS one · 2014Article
- Article
- Peptides modeled on the RGG domain of AUF1/hnRNP-D regulate 3' UTR-dependent gene expression.International immunopharmacology · 2013Article
- Identification of DEAD-box RNA helicase 6 (DDX6) as a cellular modulator of vascular endothelial growth factor expression under hypoxia.The Journal of biological chemistry · 2013Article
- Hsp70 is a novel posttranscriptional regulator of gene expression that binds and stabilizes selected mRNAs containing AU-rich elements.Molecular and cellular biology · 2013Article
- The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA.PLoS biology · 2013Article
- p16INK4A represses breast stromal fibroblasts migration/invasion and their VEGF-A-dependent promotion of angiogenesis through Akt inhibition.Neoplasia (New York, N.Y.) · 2012Article
- Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- 3'-UTR-located inverted Alu repeats facilitate mRNA translational repression and stress granule accumulation.Nucleus (Austin, Tex.) · 2012Article
- AUF1/hnRNP D represses expression of VEGF in macrophages.Molecular biology of the cell · 2012Article
- Regulation of cytoplasmic mRNA decay.Nature reviews. Genetics · 2012Review
- The expression levels of microRNA-361-5p and its target VEGFA are inversely correlated in human cutaneous squamous cell carcinoma.PloS one · 2012Article
- Post-transcriptional control of gene expression by AUF1: mechanisms, physiological targets, and regulation.Biochimica et biophysica actaReview
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
The von Hippel-Lindau (VHL) tumor suppressor gene product is the recognition component of an E3 ubiquitin ligase and is inactivated in patients with VHL disease and in most sporadic clear-cell renal cell carcinomas (RCC). pVHL controls oxygen-responsive gene expression at the transcriptional and posttranscriptional levels. The VEGFA mRNA contains AU-rich elements (ARE) in the 3'-untranslated region, and mRNA stability or decay is determined through ARE-associated RNA-binding factors. We show here that levels of the ARE-binding factor, AUF1, are regulated by pVHL and by hypoxia. pVHL and AUF1 stably associate with each other in cells and AUF1 is a ubiquitylation target of pVHL. AUF1 and another RNA-binding protein, HuR, bind to VEGFA ARE RNA. Ribonucleoprotein (RNP) immunoprecipitations showed that pVHL associates indirectly with VEGFA mRNA through AUF1 and/or HuR, and this complex is associated with VEGFA mRNA decay under normoxic conditions. Under hypoxic conditions pVHL is downregulated, whereas AUF1 and HuR binding to VEGF mRNA is maintained, and this complex is associated with stabilized mRNA. These studies suggest that AUF1 and HuR bind to VEGFA ARE RNA under both normoxic and hypoxic conditions, and that a pVHL-RNP complex determines VEGFA mRNA decay. These studies further implicate the ubiquitin-proteasome system in ARE-mediated RNA degradation.
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