ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2012
Role for ion transport in porcine vocal fold epithelial defense to acid challenge.
Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Prolonged phonation impairs the integrity and barrier function of porcine vocal fold epithelium: a preliminary study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Article
- An in vitro scaffold-free epithelial-fibroblast coculture model for the larynx.The Laryngoscope · 2017Article
- In vivo investigation of acidified pepsin exposure to porcine vocal fold epithelia.The Laryngoscope · 2016Article
- Acute Acrolein Exposure Induces Impairment of Vocal Fold Epithelial Barrier Function.PloS one · 2016Article
- Climate, vocal folds, and tonal languages: Connecting the physiological and geographic dots.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Effects of phonation time and magnitude dose on vocal fold epithelial genes, barrier integrity, and function.The Laryngoscope · 2014Article
- Vocal fold epithelial barrier in health and injury: a research review.Journal of speech, language, and hearing research : JSLHR · 2014Review
- Vocal fold ion transport and mucin expression following acrolein exposure.The Journal of membrane biology · 2014Article
- Bicarbonate availability for vocal fold epithelial defense to acidic challenge.The Annals of otology, rhinology, and laryngology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe vocal fold epithelium is routinely exposed to gastric contents, including acid and pepsin, during laryngopharyngeal reflux events. The epithelium may possess intrinsic defenses to reflux. The first objective of the current study was to examine whether vocal fold epithelial ion transport is one potential mechanism of defense to gastric contents. The second objective was to determine whether ion transport in response to gastric contents is associated with the secretion of bicarbonate. STUDY
designProspective design in excised porcine larynges.
settingLaboratory. SUBJECTS AND
methodsPorcine vocal folds (N = 56) were exposed on the luminal surface to acid, pepsin, or sham challenges. Ion transport at baseline and following challenge exposure was measured using electrophysiological techniques. To examine specific ion transport mechanisms, vocal folds were pretreated with either a sodium channel blocker or bicarbonate channel blocker.
resultsWithin 60 seconds of acid but not pepsin exposure, there was a significant increase in ion transport. This rapid increase in ion transport was transient and related to bicarbonate secretion.
conclusionThe current data suggest that porcine vocal folds immediately increase bicarbonate secretion following exposure to acid. Bicarbonate secretion may act to neutralize acid. These findings contribute to the identification of the mechanisms underlying vocal fold defense to reflux and offer implications for the development of treatments for reflux-induced vocal fold injury.
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