ArticleCancer2012
Current or recent pregnancy is associated with adverse pathologic features but not impaired survival in early breast cancer.
Article in Cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prognosis of Pregnancy-Associated Breast Cancer: A Systematic Review of Contemporary Observational Studies.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Use of trastuzumab in treating breast cancer during pregnancy: a systematic review and meta-analysis.BMC women's health · 2021Pooled it
- Prognosis of pregnancy-associated breast cancer: a meta-analysis.BMC cancer · 2020Pooled it
- Diagnosis and treatment of breast cancer during pregnancy: a comprehensive review.Frontiers in medicine · 2026Review
- Mass Spectrometry-Based Proteomics Analysis of Breast Milk for Breast Cancer Biomarker Discovery: An Update.Advances in experimental medicine and biology · 2026Review
- Pregnancy-associated breast cancer: gestational weight gain impact and nomogram validation.BMC cancer · 2025Article
- Article
- Impact of Pregnancy on Breast Cancer Features and Prognosis.Current oncology (Toronto, Ont.) · 2024Article
- The effect of parity, breastfeeding history, and duration on clinical and pathological characteristics of breast cancer patients.Turkish journal of medical sciences · 2024Article
- Survival probabilities and prognostic factors of pregnancy-associated breast cancer in Malaysian women.Obstetrics & gynecology science · 2024Article
- Pregnancy-associated breast cancer: does timing of presentation affect outcome?Breast cancer research and treatment · 2023Article
- Immune microenvironment dynamics in breast cancer during pregnancy: impact of gestational age on tumor-infiltrating lymphocytes and prognosis.Frontiers in oncology · 2023Article
- Long-Term Breast Cancer Outcomes of Pregnancy-Associated Breast Cancer (PABC) in a Prospective Cohort.Cancers · 2022Article
- Genomic copy number alterations as biomarkers for triple negative pregnancy-associated breast cancer.Cellular oncology (Dordrecht, Netherlands) · 2022Article
- Timing of Presentation and Outcomes of Women with Stage IV Pregnancy-Associated Breast Cancer (PABC).Annals of surgical oncology · 2022Article
- Clinicopathological features and prognosis of patients with pregnancy-associated breast cancer: A matched case control study.Asia-Pacific journal of clinical oncology · 2021Article
- Germline mutations in a clinic-based series of pregnancy associated breast cancer patients.BMC cancer · 2021Article
- Pregnancy-associated breast cancer: nationwide Dutch study confirms a discriminatory aggressive histopathologic profile.Breast cancer research and treatment · 2021Article
- Maternal survival of patients with pregnancy-associated cancers in Taiwan - A national population-based study.Cancer medicine · 2020Article
- Clinical features and survival of pregnancy-associated breast cancer: a retrospective study of 203 cases in China.BMC cancer · 2020Article
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPregnancy-associated breast cancer (PABC) may be defined as breast cancer diagnosed during pregnancy or within 1 year of giving birth. Conflicting data exist regarding the impact of pregnancy on clinical features and prognosis of breast cancer.
methodsA single-institution retrospective chart review was performed of 99 patients identified with PABC between 1992 and 2007. Non-PABC controls were matched 2:1 to PABC cases by year of diagnosis and age. The differences in clinical features were compared between cases and controls using chi-square tests. Univariate and multivariate analyses were performed to assess the effect of PABC on survival.
resultsOf the 99 PABC cases, breast cancer was diagnosed during pregnancy in 36 patients, and after delivery in 63. PABC cases were more likely than controls to be negative for estrogen receptor (59% vs 31%, P < .0001) and negative for progesterone receptor (72% vs 40%, P < .0001). Cases were also more likely to have advanced T class (P = .0271) and N class (P = .0104) and higher grade tumors (P = .0115). With a median follow-up of 6.3 years for cases and 4.7 years for controls, overall survival did not differ between cases and controls (P = .0787). On multivariate analysis, the independent prognostic factors for overall survival were estrogen receptor status (P = .0031) and N class (P = .0003). The diagnosis of PABC was not an independent prognostic factor (P = .1317).
conclusionsPABC is associated with more adverse tumor features than non-PABC matched for age and year of diagnosis. After correcting for pathologic features, the diagnosis of PABC is not in itself an adverse prognostic factor for survival.
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