ArticleClinics (Sao Paulo, Brazil)2011
Mechanical evaluation of the resistance and elastance of post-burn scars after topical treatment with tretinoin.
Article in Clinics (Sao Paulo, Brazil), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- From RCT to mechanistic study: ATRA reverses myofibroblast activation by reprogramming glucose metabolism via HIC1 and PCK1/2 to attenuate hypertrophic scar formation.Military Medical Research · 2026Trial
- An Updated Review of Topical Tretinoin in Dermatology: From Acne and Photoaging to Skin Cancer.Journal of clinical medicine · 2025Review
- Letter in Reply: Microneedling in the Treatment of Post-burn Hypertrophic Scars.Aesthetic plastic surgery · 2025Article
- Microneedling in the Treatment of Post-burn Hypertrophic Scars.Aesthetic plastic surgery · 2024Article
- Pharmacotherapy for Keloids and Hypertrophic Scars.International journal of molecular sciences · 2024Review
- The Burn Wound Microenvironment.Advances in wound care · 2016Review
- A systematic review of objective burn scar measurements.Burns & trauma · 2016Review
- Burn wound healing and treatment: review and advancements.Critical care (London, England) · 2015Review
- All-trans retinoic Acid reduces joint adhesion formation: an experimental study in rats.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Intra-articular adhesion reduction after knee surgery in rabbits by calcium channel blockers.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Calcium channel blockers in reduction of epidural fibrosis and dural adhesions in laminectomy rats.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAfter burn injuries, scarred skin lacks elasticity, especially in hypertrophic scars. Topical treatment with tretinoin can improve the appearance and quality of the skin (i.e., texture, distensibility, color, and hydration). The objective of this prospective study was to examine the effects of treatment with 0.05% tretinoin for one year on the biomechanical behavior and histological changes undergone by facial skin with post-burn scarring.
settingTertiary, Institutional.
methodFifteen female patients who had suffered partial thickness burns with more than two years of evolution were selected. Skin biopsies were obtained initially and after one year of treatment. The resistance and elastance of these skin biopsies were measured using a mechanical oscillation analysis system. The density of collagen fibers, elastic fibers, and versican were determined using immunohistochemical analysis.
resultsTretinoin treatment significantly lowered skin resistance and elastance, which is a result that indicates higher distensibility of the skin. However, tretinoin treatment did not significantly affect the density of collagen fibers, elastic fibers, or versican.
conclusionTopical tretinoin treatment alters the mechanical behavior of post-burn scarred skin by improving its distensibility and thus leads to improved quality of life for patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.