ArticleClinics (Sao Paulo, Brazil)2011
Gender differences, polypharmacy, and potential pharmacological interactions in the elderly.
Article in Clinics (Sao Paulo, Brazil), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Drug-drug interaction software in clinical practice: a systematic review.European journal of clinical pharmacology · 2015Pooled it
- The predictive and prognostic value of sex in early-stage colon cancer: a pooled analysis of 33,345 patients from the ACCENT database.Clinical colorectal cancer · 2013Trial
- Polypharmacy and quality of life in Yemeni cancer patients undergoing chemotherapy: A cross-sectional study.PLOS global public health · 2026Article
- A trajectory-informed model for detecting drug-drug-host interaction from real-world data.Journal of biomedical informatics · 2025Article
- Potential drug-drug interactions among geriatric oncology patients: a retrospective study in Saudi Arabia.BMC geriatrics · 2025Article
- Polypharmacy Prevalence Among Older Adults Based on the Survey of Health, Ageing and Retirement in Europe: An Update.Journal of clinical medicine · 2025Article
- Adverse event profile of five anti head and neck squamous cell carcinoma drugs: a descriptive analysis from WHO-VigiAccess.Frontiers in pharmacology · 2025Article
- Evaluation of the prevalence and influencing factors on poly-pharmacy among elderly patients - A review.Journal of family medicine and primary care · 2024Review
- Prevalence and differences in the co-administration of drugs known to interact: an analysis of three distinct and large populations.BMC medicine · 2024Article
- Polypharmacy in Older Patients: A Three-Year Longitudinal Analysis in Primary Care Settings of Aragón, Spain.Annals of geriatric medicine and research · 2024Article
- Functional Status in Relation to Common Geriatric Syndromes and Sociodemographic Variables - A Step Forward Towards Healthy Aging.Clinical interventions in aging · 2024Article
- Potentially Inappropriate Medications Use and Associated Factors Among Older Patients on Follow-Up at the Chronic Care Clinic of Hiwot Fana Comprehensive Specialized Hospital in Eastern Ethiopia.Current therapeutic research, clinical and experimental · 2024Article
- Potential Drug-Drug Interactions and Related Factors among Geriatric Outpatients of a Tertiary Care Hospital.Geriatrics (Basel, Switzerland) · 2023Article
- Gender Differences in Potentially Inappropriate Medication Use among Older Adults.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Polypharmacy and the Change of Self-Rated Health in Community-Dwelling Older Adults.International journal of environmental research and public health · 2023Article
- Association Between Multi-Morbidities and Polypharmacy Among Older Adults at an Academic Medical Center in Saudi Arabia.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2023Article
- Polypharmacy and associated factors: a gender perspective in the elderly Spanish population (2011-2020).Frontiers in pharmacology · 2023Article
- Factors associated with polypharmacy and the high risk of medication-related problems among older community-dwelling adults in European countries: a longitudinal study.BMC geriatrics · 2022Article
- PCSK9 Inhibitor: Safe Alternative to Fill the Treatment Gap in Statin-Limited Conditions?Reviews in cardiovascular medicine · 2022Review
- Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to analyze pharmacological interactions among drugs taken by elderly patients and their age and gender differences in a population from Porto Alegre, Brazil.
methodsWe retrospectively analyzed the database provided by the Institute of Geriatric and Gerontology, Porto Alegre, Brazil. The database was composed of 438 elderly and includes information about the patients' disease, therapy regimens, utilized drugs. All drugs reported by the elderly patients were classified using the Anatomical Therapeutic and Chemical Classification System. The drug-drug interactions and their severity were assessed using the Micromedex® Healthcare Series.
resultsOf the 438 elderly patients in the data base, 376 (85.8%) used pharmacotherapy, 274 were female, and 90.4% of females used drugs. The average number of drugs used by each individual younger than 80 years was 3.2±2.6. Women younger than 80 years old used more drugs than men in the same age group whereas men older than 80 years increased their use of drugs in relation to other age groups. Therefore, 32.6% of men and 49.2% of women described at least one interaction, and 8.1% of men and 10.6% of women described four or more potential drug-drug interactions. Two-thirds of drug-drug interactions were moderate in both genders, and most of them involved angiotensin-converting enzyme inhibitor, non-steroidal anti-inflammatory, loop and thiazide diuretics, and β-blockers.
conclusionElderly patients should be closely monitored, based on drug class, gender, age group and nutritional status.
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