ArticleLearning & memory (Cold Spring Harbor, N.Y.)2011
Anterior thalamic lesions alter both hippocampal-dependent behavior and hippocampal acetylcholine release in the rat.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Paired associates learning is disrupted after unilateral parietal lobe controlled cortical impact in rats: A trial-by-trial behavioral analysis.Behavioural brain research · 2023Article
- Time to retire the serial Papez circuit: Implications for space, memory, and attention.Neuroscience and biobehavioral reviews · 2022Review
- Anterior thalamic circuits crucial for working memory.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The limbic memory circuit and the neural basis of contextual memory.Neurobiology of learning and memory · 2022Article
- Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function.Neuropsychology review · 2021Review
- Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models.Neuron · 2021Article
- Mammillothalamic Disconnection Alters Hippocampocortical Oscillatory Activity and Microstructure: Implications for Diencephalic Amnesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Sex-Dependent Differences in Physical Exercise-Mediated Cognitive Recovery Following Middle Cerebral Artery Occlusion in Aged Rats.Frontiers in aging neuroscience · 2019Article
- Nerve Growth Factor Is Responsible for Exercise-Induced Recovery of Septohippocampal Cholinergic Structure and Function.Frontiers in neuroscience · 2018Article
- Navigating Monogamy: Nonapeptide Sensitivity in a Memory Neural Circuit May Shape Social Behavior and Mating Decisions.Frontiers in neuroscience · 2017Review
- Environmental Anchoring of Head Direction in a Computational Model of Retrosplenial Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The reuniens and rhomboid nuclei: neuroanatomy, electrophysiological characteristics and behavioral implications.Progress in neurobiology · 2013Review
- Thiamine deficiency induced neurochemical, neuroanatomical, and neuropsychological alterations: a reappraisal.TheScientificWorldJournal · 2013Review
- The anterior thalamus is critical for overcoming interference in a context-dependent odor discrimination task.Behavioral neuroscience · 2012Article
- Translational rodent models of Korsakoff syndrome reveal the critical neuroanatomical substrates of memory dysfunction and recovery.Neuropsychology review · 2012Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The anterior thalamic nuclei (ATN) are important for learning and memory as damage to this region produces a persistent amnestic syndrome. Dense connections between the ATN and the hippocampus exist, and importantly, damage to the ATN can impair hippocampal functioning. Acetylcholine (ACh) is a key neurotransmitter in the hippocampus, and in vivo measures of ACh are correlated to learning and memory performance. In the present study, complete lesions of the ATN impaired performance on two measures of hippocampal-dependent learning and memory (spontaneous alternation and delayed alternation) and severely disrupted behaviorally evoked ACh efflux within the hippocampus of adult male rats. In contrast, incomplete ATN lesions did not impair spontaneous alternation performance but did impair delayed alternation performance while blunting hippocampal ACh efflux. Interestingly, ATN lesions of any size did not affect basal concentrations of ACh in the hippocampus. These results demonstrate that the ATN have the capacity to modulate behaviorally relevant neuronal transmission within the hippocampus.
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Registered trials
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