Evidence map›Paper›PMID 22086373›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2012

Exploring the role of miRNAs in renal cell carcinoma progression and metastasis through bioinformatic and experimental analyses.

Heba W Z Khella, Nicole M A White, Hala Faragalla, Manal Gabril, Mina Boazak, David Dorian, Bishoy Khalil, Hany Antonios, Tian Tian Bao, Maria D Pasic and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Quantitative assessment of the association between microRNA-499 rs3746444 A/G polymorphism and cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
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  16. miR-335 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells through direct suppression of BCL-W.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Heba W Z KhellaDepartment of Laboratory Medicine and the Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael's Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada.
Nicole M A White
Hala Faragalla
Manal Gabril
Mina Boazak
David Dorian
Bishoy Khalil
Hany Antonios
Tian Tian Bao
Maria D Pasic
R John Honey
Robert Stewart
Kenneth T Pace
Georg A Bjarnason
Michael A S Jewett
George M Yousef
St. Michael's Hospital · CAUniversity of Toronto · CALondon Health Sciences Centre · CASt Michael's Hospital · GBSunnybrook Health Science Centre · CA

Funding

Canadian Institutes of Health Research 86490
6 · The paper itself

Abstract

Metastasis results in most of the cancer deaths in clear cell renal cell carcinoma (ccRCC). MicroRNAs (miRNAs) regulate many important cell functions and play important roles in tumor development, metastasis and progression. In our previous study, we identified a miRNA signature for metastatic RCC. In this study, we validated the top differentially expressed miRNAs on matched primary and metastatic ccRCC pairs by quantitative polymerase chain reaction. We performed bioinformatics analyses including target prediction and combinatorial analysis of previously reported miRNAs involved in tumour progression and metastasis. We also examined the co-expression of the miRNAs clusters and compared expression of intronic miRNAs and their host genes. We observed significant dysregulation between primary and metastatic tumours from the same patient. This indicates that, at least in part, the metastatic signature develops gradually during tumour progression. We identified metastasis-dysregulated miRNAs that can target a number of genes previously found to be involved in metastasis of kidney cancer as well as other malignancies. In addition, we found a negative correlation of expression of miR-126 and its target vascular endothelial growth factor (VEGF)-A. Cluster analysis showed that members of the same miRNA cluster follow the same expression pattern, suggesting the presence of a locus control regulation. We also observed a positive correlation of expression between intronic miRNAs and their host genes, thus revealing another potential control mechanism for miRNAs. Many of the significantly dysregulated miRNAs in metastatic ccRCC are highly conserved among species. Our analysis suggests that miRNAs are involved in ccRCC metastasis and may represent potential biomarkers.

Indexed as

Biomarkers, TumorCarcinoma, Renal CellComputational BiologyHumansKidney NeoplasmsMaleMicroRNAsNeoplasm MetastasisOligonucleotide Array Sequence AnalysisVascular Endothelial Growth Factor ABiomarkers, TumorMicroRNAsVascular Endothelial Growth Factor A

Identifiers

PMID22086373
OpenAlexW1972784754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.